ID A0A1M7RAD7_9ACTN Unreviewed; 443 AA.
AC A0A1M7RAD7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:SHN43315.1};
GN ORFNames=SAMN05443668_109113 {ECO:0000313|EMBL:SHN43315.1};
OS Cryptosporangium aurantiacum.
OC Bacteria; Actinomycetota; Actinomycetes; Cryptosporangiales;
OC Cryptosporangiaceae; Cryptosporangium.
OX NCBI_TaxID=134849 {ECO:0000313|EMBL:SHN43315.1, ECO:0000313|Proteomes:UP000184440};
RN [1] {ECO:0000313|EMBL:SHN43315.1, ECO:0000313|Proteomes:UP000184440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46144 {ECO:0000313|EMBL:SHN43315.1,
RC ECO:0000313|Proteomes:UP000184440};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
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DR EMBL; FRCS01000009; SHN43315.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M7RAD7; -.
DR STRING; 134849.SAMN05443668_109113; -.
DR OrthoDB; 9762169at2; -.
DR Proteomes; UP000184440; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR43671:SF13; LD04361P; 1.
DR PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:SHN43315.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000184440};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:SHN43315.1};
KW Transferase {ECO:0000313|EMBL:SHN43315.1}.
FT DOMAIN 42..95
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 175..439
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 203
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 443 AA; 47861 MW; DA1BCCF43D93C4E3 CRC64;
MLCADATLGA RIDDVVTATI VLRVVTGRLQ PDEYVFDQRT TCVIGRADGC RPQLPDDEHH
RRVSRHHCLL DLNPPAARVR DFGSLNGTYL NGVRIGRRPP GRSAEDAAGE VYPEHDLADG
DELRVGDTTF RVSIEQPVSA REPEAPADAH PRAVAERILA AADARRPGLA SIAGYTLLRE
LGRGGNGAVY LASRSGGTPV ALKIMLPRVA GNEKAREQFL RETEVTRQLR HPHVAALYEA
GAAEGGFYFT VEYCDGGSMD ALLERAGGTL PVRQAVEIAV QALEGLEYAH AQGIVHRDLS
PHNILLTGTG DQLMAKIADF GLAKAFDQAG LSGLTRTGAV AGKPVYLPRQ QMINFREARP
EVDVWSLAAC LYQALTGEFP RDFSSGRDPW LIVLQDPAVP IRDRDPGVPA ALAEVIDRAL
EENPQPGIAT AADLRHALRS ALR
//
