ID A0A1M7RHI0_9ACTN Unreviewed; 524 AA.
AC A0A1M7RHI0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Uroporphyrinogen III methyltransferase / synthase {ECO:0000313|EMBL:SHN45622.1};
GN ORFNames=SAMN05443668_112158 {ECO:0000313|EMBL:SHN45622.1};
OS Cryptosporangium aurantiacum.
OC Bacteria; Actinomycetota; Actinomycetes; Cryptosporangiales;
OC Cryptosporangiaceae; Cryptosporangium.
OX NCBI_TaxID=134849 {ECO:0000313|EMBL:SHN45622.1, ECO:0000313|Proteomes:UP000184440};
RN [1] {ECO:0000313|EMBL:SHN45622.1, ECO:0000313|Proteomes:UP000184440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46144 {ECO:0000313|EMBL:SHN45622.1,
RC ECO:0000313|Proteomes:UP000184440};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; FRCS01000012; SHN45622.1; -; Genomic_DNA.
DR RefSeq; WP_073262356.1; NZ_FRCS01000012.1.
DR AlphaFoldDB; A0A1M7RHI0; -.
DR STRING; 134849.SAMN05443668_112158; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000184440; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SHN45622.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000184440};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SHN45622.1}.
FT DOMAIN 9..206
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 257..488
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 524 AA; 54398 MW; 3596A11CF5DAD069 CRC64;
MTRRSTTGRI TFVGAGPGDP GLLTRRALDA VADADHILHD RSLPAPLLAA VVAAAPAEVE
VSVAEGAAGD IAKVLLSGAR SGRTVARLVA GDPLTAESIV REVQAVARTS VPFEVVPGVP
LAEGVTGYAG APTGGLRTTV EVRDVTALDF DAMVAVPGSL TLTLDAGDLP AVRDGLLAAG
MSGQATVLVT GDGTTDTQST SVSTLDGIVD AAIGLYGTLV VSIGAGVGLR DKLSWWESRP
LYGWKVLVPR TKEQAGAMSA QLRGWGAIPE EVPTIAVEPP RTPAQMERAI KGLVTGRYEW
VIFTSTNAVK AVWEKFAEFG LDARAFAGVK IACVGDATAA AVQSFGVRPE LLPSGEQSSD
GLLADFPPYD EVLDPIDRIL LPRADIATET LAAGLIERGW EVDDVTAYRT VRAAPPPAPI
RDAIKSGGFD AVLFTSSSTV RNLVGIAGKP HARTVVACIG PKTADTAREL GLRVDVQPET
ANVPSLVESL AEYALELREK LAALPTKPRR GAKAQGPTAG RLAR
//