ID A0A1M7SCP9_FERGO Unreviewed; 668 AA.
AC A0A1M7SCP9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Iron-hydrogenase subunit alpha {ECO:0000313|EMBL:SHN56250.1};
GN ORFNames=SAMN02745226_00748 {ECO:0000313|EMBL:SHN56250.1};
OS Fervidobacterium gondwanense DSM 13020.
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC Fervidobacterium.
OX NCBI_TaxID=1121883 {ECO:0000313|EMBL:SHN56250.1, ECO:0000313|Proteomes:UP000184207};
RN [1] {ECO:0000313|EMBL:SHN56250.1, ECO:0000313|Proteomes:UP000184207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13020 {ECO:0000313|EMBL:SHN56250.1,
RC ECO:0000313|Proteomes:UP000184207};
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FRDJ01000003; SHN56250.1; -; Genomic_DNA.
DR RefSeq; WP_072758506.1; NZ_FRDJ01000003.1.
DR AlphaFoldDB; A0A1M7SCP9; -.
DR STRING; 1121883.SAMN02745226_00748; -.
DR OrthoDB; 9803192at2; -.
DR Proteomes; UP000184207; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR CDD; cd02980; TRX_Fd_family; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.1780; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 4.10.260.20; Iron hydrogenase, small subunit; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR InterPro; IPR003149; Fe_hydrogenase_ssu.
DR InterPro; IPR036991; Fe_hydrogenase_ssu_sf.
DR InterPro; IPR013352; Fe_hydrogenase_subset.
DR InterPro; IPR000283; NADH_UbQ_OxRdtase_75kDa_su_CS.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR NCBIfam; TIGR02512; FeFe_hydrog_A; 1.
DR PANTHER; PTHR11615:SF6; NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR Pfam; PF01257; 2Fe-2S_thioredx; 1.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR Pfam; PF02256; Fe_hyd_SSU; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR SMART; SM00902; Fe_hyd_SSU; 1.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF53920; Fe-only hydrogenase; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
DR PROSITE; PS00641; COMPLEX1_75K_1; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 1..77
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 77..116
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 135..165
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 178..207
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 668 AA; 73829 MW; 9667DBED3C651C45 CRC64;
MRIIVNGREI EIRDDARNVL EALREVGIEI PNLCYLSETS VYGACRMCLV EVDGRDIVTS
CTLQPREGMV IKTHTPKIYE MRKGILQLLL ASHDGECTTC EMNGKCKLQK YAQEFGLTTN
RFEKISKKTV TDTSSVIVRD NGKCILCGDC VRACDEIQGI AAIDFAYRGF EAQVVPSFEE
KLENTECVLC GQCVAYCPTG ALAIRNDVDK VYKAIEDGKY VIGMIAPAVR ASLQEEFGLE
DDVATSGRVV SLLKMIGFKK VFDVAFAADL VAYEEAHEFL ERVEKGEKLP QFTSCCPGWV
KFAEQYYPEY ISHLSSVKSP QMALGAIIKK FYSREIGVDP KDIVLVSIMP CTAKKFEAER
EEFEGNVDIV LTTRELVKVI KSTGIDIKMV DPEPFDRPYG LSSQSGLSFG KTGGVLGSVV
NVINDKMSVK SVETKQLSEG VSLTTVELSN GKVVKGLAVF GLGNARKIVD ALKNGEMEAD
VVEVMACNYG CIGGGGQPYP NDVRTRARRA KILKEVQSID VLISPTENFH MHQLYEKYLE
KPLSHASHEV IHTLYKHRKR VQEDEIDILP LPEETEDKVK VSVCLGTSCY SKGSYEILEK
LIAAANKEEW AKNLEIKGTF CVENCGKSPN VVVNDIIVSE ATVEKVKEVA INELSGKKGD
SKVSKSNV
//
