ID   A0A1M7TD81_FERGO        Unreviewed;       683 AA.
AC   A0A1M7TD81;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Serine protease, subtilisin family {ECO:0000313|EMBL:SHN68627.1};
GN   ORFNames=SAMN02745226_01855 {ECO:0000313|EMBL:SHN68627.1};
OS   Fervidobacterium gondwanense DSM 13020.
OC   Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC   Fervidobacterium.
OX   NCBI_TaxID=1121883 {ECO:0000313|EMBL:SHN68627.1, ECO:0000313|Proteomes:UP000184207};
RN   [1] {ECO:0000313|EMBL:SHN68627.1, ECO:0000313|Proteomes:UP000184207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13020 {ECO:0000313|EMBL:SHN68627.1,
RC   ECO:0000313|Proteomes:UP000184207};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
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DR   EMBL; FRDJ01000014; SHN68627.1; -; Genomic_DNA.
DR   RefSeq; WP_072760817.1; NZ_FRDJ01000014.1.
DR   AlphaFoldDB; A0A1M7TD81; -.
DR   STRING; 1121883.SAMN02745226_01855; -.
DR   OrthoDB; 9798386at2; -.
DR   Proteomes; UP000184207; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1800; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}.
FT   DOMAIN          192..462
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        201
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        239
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        414
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   683 AA;  75003 MW;  A7FC863F4D2F9B51 CRC64;
     MKSKLLLSNK KYTFNLKSLL WKSKLVFVFL IIGLVISIAT SCTNSRSGRI DNGSTSDLSE
     NLSLTNDDYF PDRVLVGYED EDDLDKIAEL IEGRLLLNIP QIRVASFKVE KVEKVLQIFQ
     DEESIQKVKI RYAEPVYKRS IIPYSVGQGY SNQKVVLNYT IYENYTSESL DFYLWGLRAI
     DVKKVWNDGY DGTGIIVAVL DTGVDGTHPD LQGQVTRGYR PIINQEIPEG TDSSYGGSHG
     THVAGTIAAK KDGKGLVGVA PRVKIMPVVL FDIGGWYVGD DYAAKGIIWA VDHGAKVLSN
     SWGGAGYSQT LKDAFDYALA HGVVVVAAAG NSKSSQSFQY PANYPGVIQV GAVEYLGNKY
     DIADFSSGSP MLSVSAPGVN IISTMPQKTS VGYDKRSFQI AENSGYYGFM SGTSMATPHV
     SGFVALLLQE YPNAKPWQIR RLLENGAIDI GEPGIDERSG YGMINQRSVS SELPDNGGLN
     LDVEVTDAYG DWKIPSVSVS LIGTSNTDRR VRYFSKTNGD GVAKFLNIDT GKYDVIISGP
     DSRENSEGLS NVVYRKAEER VYYANRSFTN DSSITFNFSS QARIKFKNVS GNEFLILQSK
     DGSTSTTIEL LSNQIDISHL SGRYFIKFGY PSPVLHNTTV NATITLNGYD IRLSGYITAG
     STLTTLYDAY GRNSHWTFFG KTE
//