ID A0A1M7Y5T2_9FIRM Unreviewed; 506 AA.
AC A0A1M7Y5T2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN02745217_01627 {ECO:0000313|EMBL:SHO47694.1};
OS Anaerocolumna xylanovorans DSM 12503.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerocolumna.
OX NCBI_TaxID=1121345 {ECO:0000313|EMBL:SHO47694.1, ECO:0000313|Proteomes:UP000184612};
RN [1] {ECO:0000313|EMBL:SHO47694.1, ECO:0000313|Proteomes:UP000184612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12503 {ECO:0000313|EMBL:SHO47694.1,
RC ECO:0000313|Proteomes:UP000184612};
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
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DR EMBL; FRFD01000004; SHO47694.1; -; Genomic_DNA.
DR RefSeq; WP_073588324.1; NZ_FRFD01000004.1.
DR AlphaFoldDB; A0A1M7Y5T2; -.
DR STRING; 1121345.SAMN02745217_01627; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000184612; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000184612};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 6..218
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 267..494
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 506 AA; 55027 MW; 2769A197C7563FAA CRC64;
MEKSGKVYLV GAGPGDPALL TLKGRRLLQA CDAVIYDRLV SEELLDYAKE DCERIFVGKT
VGNHALKQEE INQIIIEKAL THPVVVRLKG GDPFVFGRGG EEVLALKEQG ISYEVVPGVT
SAIAAAAYAG IPVTHRGSSQ SFTVITGHTA EEEGNIPDSL TSLAQTSGTL IILMGISNLD
RIAEKLLEGG KHPDTPVAVV SNGTTPWQKE VRGSLADICQ KVKEAGIKAP AVIIVGSVAG
LDMKATIRCP LSGVNIGITG TREIREKLIQ QLHELGANTV TAGSLEIIDY SGKPEFDRAL
MSLEQYHWIV FTSSNAVNLF FQRLAKLGID HRKLSHIRFA VVGSGTSKIL MQYGYHADLV
PQQYSAFHLA QELCNIVTAE EKLLIPRAMQ GSEELITVLD DNNISYEEIK IYDVVSSYYT
PEPGEKQIER LDYLVFASSS GVHGFFQDSD SSTRELLECT KIVCIGEATQ RTLSEYGYAN
TLTAKEASVK GIVECIVENN RNDGIE
//