ID A0A1M8AAT4_MALS4 Unreviewed; 949 AA.
AC A0A1M8AAT4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Similar to S.cerevisiae protein MSH2 (Protein that binds to DNA mismatches) {ECO:0000313|EMBL:SHO79539.1};
GN ORFNames=MSYG_3888 {ECO:0000313|EMBL:SHO79539.1};
OS Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated
OS yeast).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=1230383 {ECO:0000313|EMBL:SHO79539.1, ECO:0000313|Proteomes:UP000186303};
RN [1] {ECO:0000313|Proteomes:UP000186303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42132 {ECO:0000313|Proteomes:UP000186303};
RX PubMed=28100699; DOI=10.1093/nar/gkx006;
RA Zhu Y., Engstroem P.G., Tellgren-Roth C., Baudo C.D., Kennell J.C., Sun S.,
RA Billmyre R.B., Schroeder M.S., Andersson A., Holm T., Sigurgeirsson B.,
RA Wu G., Sankaranarayanan S.R., Siddharthan R., Sanyal K., Lundeberg J.,
RA Nystedt B., Boekhout T., Dawson T.L. Jr., Heitman J., Scheynius A.,
RA Lehtioe J.;
RT "Proteogenomics produces comprehensive and highly accurate protein-coding
RT gene annotation in a complete genome assembly of Malassezia sympodialis.";
RL Nucleic Acids Res. 45:2629-2643(2017).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; LT671826; SHO79539.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M8AAT4; -.
DR STRING; 1230383.A0A1M8AAT4; -.
DR VEuPathDB; FungiDB:MSYG_3888; -.
DR OMA; LVRFPQK; -.
DR Proteomes; UP000186303; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000186303}.
FT DOMAIN 757..773
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 949 AA; 105867 MW; E309E3A0A6E3767B CRC64;
MSGLMYPTEE SRQSAMRSDS DKSDLNFVSF YKGMPRSIPG TIRLFDRQDY YTVHGDDALY
VADTVFRTQS VLRYLGGRGK DQAGLPSCSL NPAAAKSFLR DALTSKQLRI EIWGSTSGDG
SSRRNASWAI SKQASPGNLQ EVEDLLFLNA DVVSSPMVLA VRVKAQDGLT MVGVAFADAT
NREMGVCEYA ENDLFSNTES LIIQLGVKEC LLPGDETSTD YDINKMQGVL ERCGCIISNV
KRSQFSSKSI EEDMQRLLPA SEKALAPELD KKLAMSAAAA LLSYLHLLED ESNFGKFALR
THDLSEYLRL DHAALKALSL FPEAQGGSAL ANKHASLYGL LNRCKTAQGN RMLSQWLKQP
LVNVHAIQNR QSLLAIFMEE PELRHKIQDE YLRYMPDMLR ISKRFQRGAA TLEDVVRCYQ
AVVKVPELQS CLADVPVGLE TDQTLFHSSF AAPLEELFQH LSKLVEMVET TIDLDELAYH
NYVIKPEFDD GLRTIKAKLD QIRDQFDEQH IKAGSDLRLD TEKKLHLENH SSYGYCFRVT
RTEAGVIKNR SGYLDLGTVK GGLYFTTSAM RELNDDFRSL SDEYARTQSR LVKDVIEIAS
SYAPPLEQLN VVLAHLDVIL SLAQVSSNAP IPYTRPQILE RGADLFLVDS RHPCLEVQDD
VNFIPNNVSM VTQKSEFLLV TGPNMGGKST YLRQIGIITL MAQIGCFVPA AEGAQIPVCD
CILARVGAGD SQLKGISTFM AEMLETATIL KTATKDSLVL IDELGRGTST YDGFGLAWAI
SEWIVTHIHC KCVFATHFHE LTNLARQQPG VQNLHMVAYV APRDNGSRFD KDITLLYKVE
EGVSNQSYGI QIAELADFPD SVIRLAKRKA EELEGFDDEQ QAMDMPADVA ETGVALVQEF
MAAWRERTQA KRQKMDESEA QKEALDSCIK DFDERIRTNP WTAKVLENF
//
