ID A0A1M8LK23_9MYCO Unreviewed; 268 AA.
AC A0A1M8LK23;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Cytotoxin/haemolysin homologue TlyA {ECO:0000313|EMBL:SKQ95017.1};
DE EC=2.1.1.226 {ECO:0000313|EMBL:SKQ95017.1};
GN Name=tlyA {ECO:0000313|EMBL:SKQ95017.1};
GN ORFNames=SAMEA2070793_02022 {ECO:0000313|EMBL:SHY68306.1},
GN SAMEA2071181_02276 {ECO:0000313|EMBL:SKQ95017.1};
OS Mycobacteroides abscessus subsp. abscessus.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacteroides; Mycobacteroides abscessus.
OX NCBI_TaxID=1185650 {ECO:0000313|EMBL:SKQ95017.1, ECO:0000313|Proteomes:UP000190796};
RN [1] {ECO:0000313|Proteomes:UP000184807, ECO:0000313|Proteomes:UP000190796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=22 {ECO:0000313|EMBL:SKQ95017.1,
RC ECO:0000313|Proteomes:UP000190796}, and 425
RC {ECO:0000313|EMBL:SHY68306.1, ECO:0000313|Proteomes:UP000184807};
RG Pathogen Informatics;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TlyA family.
CC {ECO:0000256|ARBA:ARBA00029460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:SKQ95017.1}.
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DR EMBL; FSFZ01000002; SHY68306.1; -; Genomic_DNA.
DR EMBL; FVKR01000006; SKQ95017.1; -; Genomic_DNA.
DR RefSeq; WP_005079310.1; NZ_SAZC01000016.1.
DR AlphaFoldDB; A0A1M8LK23; -.
DR GeneID; 66972732; -.
DR Proteomes; UP000184807; Unassembled WGS sequence.
DR Proteomes; UP000190796; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004538; Hemolysin_A/TlyA.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR047048; TlyA.
DR NCBIfam; TIGR00478; tly; 1.
DR PANTHER; PTHR32319; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR32319:SF0; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR Pfam; PF01728; FtsJ; 1.
DR Pfam; PF01479; S4; 1.
DR PIRSF; PIRSF005578; TlyA; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:SKQ95017.1};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182};
KW Transferase {ECO:0000313|EMBL:SKQ95017.1}.
FT DOMAIN 5..71
FT /note="RNA-binding S4"
FT /evidence="ECO:0000259|SMART:SM00363"
SQ SEQUENCE 268 AA; 28022 MW; 67544CA4F77073D9 CRC64;
MARHARVDAE LVRRGLARSR QQAAELIEAG RVRIDGIPAV KAATAVPATA SLVVQGEAGD
RWVSRGAHKL LGALEVFGPQ GLSVEGKRCL DAGASTGGFT EVLLRSGARE VVAADVGYGQ
LAWSLQSDDR VTVLDRTNVR TLTPALIGGT AQLIVSDLSF ISLALVLDAL IACAGPDADI
LPMVKPQFEV GKELVGAGGV VRDPQLRADA VVSVARRARS QGWFTAGVTA SPLPGPSGNV
EYFLWLRRTD SDVDVEAAVA EAVSRGPQ
//
