ID A0A1N6KRC5_9BURK Unreviewed; 1085 AA.
AC A0A1N6KRC5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=SAMN05444165_4393 {ECO:0000313|EMBL:SIO59098.1};
OS Paraburkholderia phenazinium.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=60549 {ECO:0000313|EMBL:SIO59098.1, ECO:0000313|Proteomes:UP000185151};
RN [1] {ECO:0000313|EMBL:SIO59098.1, ECO:0000313|Proteomes:UP000185151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GAS95 {ECO:0000313|EMBL:SIO59098.1,
RC ECO:0000313|Proteomes:UP000185151};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FSRU01000002; SIO59098.1; -; Genomic_DNA.
DR RefSeq; WP_074299143.1; NZ_FSRU01000002.1.
DR AlphaFoldDB; A0A1N6KRC5; -.
DR OrthoDB; 9176627at2; -.
DR Proteomes; UP000185151; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000185151};
KW Transmembrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 466..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 534..552
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 902..921
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 928..950
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 956..979
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1000..1019
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1031..1057
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1085 AA; 116044 MW; 53AADF4AD02C60E0 CRC64;
MPRFFIDRPV FAWVIPILIC ILGVISMLNL GIDSYPDIAP PEVTVTATYP GASAATMEST
VTQVIEQQLT GIDNLLYFSS ASNSNGTVTI TLSFATGTNP DTAEVQVQNK VSLAQPLLPT
QVTQQGVVVA KASPDILMFV SLQSNNPAID ASRLSDIIAS QIQPVIARVN GVGNTFMLGS
EYAVRIWLNP DKLQGYGLST TQVLNAVSAQ NAQFATGSLG ADPAVKGQTF TATVSGDTLF
SSLKQFRDII LLTNSNGTVV RLSDVARITF GAQTYGSASV YNGKAAGGMG VYLLPGANAL
AVAKAVKAEM AILAKDLPAG VKWDVPYDTT PFITASITDV VRTLLEAIVL VFVVMLIFLQ
NLRATIIPTL VIPVALLGTF IGLSLLHYTL NQLTLFGMVL AIGIVVDDAI VVIENVERIM
TEERLPPREA TRKAMGQITG AILAITVVLA AVFVPSALQP GATGIIYAQF ALTIAVSMIV
SAFLAMSFTP ALCAAILRPT HDEHKNVVFR WFDSGLERIN RTYIRQIGGA VRHAPRWMIV
FVLLAMLAGF LYTRLPTSFV PDEDQGFMLA LVNLPTGATI QRTDQAMAEV SDKLKHSPIS
KDIAAVFQIE GFSFVGNSEN VGMAFIQLTD WDKRPETAMQ LIPQANRILH GIPDAQVFVV
NLPTIRGLSQ FGGIDMFLQA RAGQSRAQLA QAEHILLGNA AKNTTLYGIR PNSLPDAPQL
EMSVDRVHAQ AMGLSLTDVY NAIQMELAPY YVNQFTYGGR VKRVYLQADA PYRMGVDAFQ
HIYTPSGISS ASTGAASSYA DTTNTSGYLT TVNPSASNTS LSPYNMVPLS SVVKTHWDVG
PVALPRYNGY SAIEIVGNPA PGYSTGEAMK TLQHIVDTAL PSGFAADWTG QSYQEILAGN
SATLLMILSI VVVFLCLAAL YESWSIPVAV LLVVPLGMLG MLAFCLMRGI PNDIYFKIGL
VTVIGLAAKN AILIVEFAVE GQAKGMTLYD AVLSAGKLRL RPILMTSMAF ILGVFPLVIS
TGAGASSRHE IGTGVIGGML FATFLGLLLI PVFYVVVRRV LGDKLDEVSH KLPHHGDEGA
HDAGA
//
