ID A0A1N6LXD4_BABMR Unreviewed; 614 AA.
AC A0A1N6LXD4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=TATA box binding protein associated factor (TAF) histone-like fold domain-containing protein {ECO:0000259|SMART:SM00803};
GN ORFNames=BmR1_04g05297 {ECO:0000313|EMBL:SIO73538.1};
OS Babesia microti (strain RI).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=1133968 {ECO:0000313|EMBL:SIO73538.1, ECO:0000313|Proteomes:UP000002899};
RN [1] {ECO:0000313|EMBL:SIO73538.1, ECO:0000313|Proteomes:UP000002899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RI {ECO:0000313|EMBL:SIO73538.1,
RC ECO:0000313|Proteomes:UP000002899};
RX PubMed=22833609; DOI=10.1093/nar/gks700;
RA Cornillot E., Hadj-Kaddour K., Dassouli A., Noel B., Ranwez V.,
RA Vacherie B., Augagneur Y., Bres V., Duclos A., Randazzo S., Carcy B.,
RA Debierre-Grockiego F., Delbecq S., Moubri-Menage K., Shams-Eldin H.,
RA Usmani-Brown S., Bringaud F., Wincker P., Vivares C.P., Schwarz R.T.,
RA Schetters T.P., Krause P.J., Gorenflot A., Berry V., Barbe V.,
RA Ben Mamoun C.;
RT "Sequencing of the smallest Apicomplexan genome from the human pathogen
RT Babesia microti.";
RL Nucleic Acids Res. 40:9102-9114(2012).
RN [2] {ECO:0000313|EMBL:SIO73538.1, ECO:0000313|Proteomes:UP000002899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RI {ECO:0000313|EMBL:SIO73538.1,
RC ECO:0000313|Proteomes:UP000002899};
RX PubMed=24023759; DOI=10.1371/journal.pone.0072657;
RA Cornillot E., Dassouli A., Garg A., Pachikara N., Randazzo S., Depoix D.,
RA Carcy B., Delbecq S., Frutos R., Silva J.C., Sutton R., Krause P.J.,
RA Mamoun C.B.;
RT "Whole genome mapping and re-organization of the nuclear and mitochondrial
RT genomes of Babesia microti isolates.";
RL PLoS ONE 8:e72657-e72657(2013).
RN [3] {ECO:0000313|EMBL:SIO73538.1, ECO:0000313|Proteomes:UP000002899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RI {ECO:0000313|EMBL:SIO73538.1,
RC ECO:0000313|Proteomes:UP000002899};
RX PubMed=27752055; DOI=10.1038/srep35284;
RA Silva J.C., Cornillot E., McCracken C., Usmani-Brown S., Dwivedi A.,
RA Ifeonu O.O., Crabtree J., Gotia H.T., Virji A.Z., Reynes C., Colinge J.,
RA Kumar V., Lawres L., Pazzi J.E., Pablo J.V., Hung C., Brancato J.,
RA Kumari P., Orvis J., Tretina K., Chibucos M., Ott S., Sadzewicz L.,
RA Sengamalay N., Shetty A.C., Su Q., Tallon L., Fraser C.M., Frutos R.,
RA Molina D.M., Krause P.J., Ben Mamoun C.;
RT "Genome-wide diversity and gene expression profiling of Babesia microti
RT isolates identify polymorphic genes that mediate host-pathogen
RT interactions.";
RL Sci. Rep. 6:35284-35284(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF6 family.
CC {ECO:0000256|ARBA:ARBA00007688}.
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DR EMBL; LN871599; SIO73538.1; -; Genomic_DNA.
DR RefSeq; XP_012649666.1; XM_012794212.1.
DR AlphaFoldDB; A0A1N6LXD4; -.
DR GeneID; 33043747; -.
DR KEGG; bmic:BmR1_04g05297; -.
DR VEuPathDB; PiroplasmaDB:BmR1_04g05297; -.
DR OrthoDB; 232018at2759; -.
DR Proteomes; UP000002899; Chromosome iv.
DR GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd08050; TAF6C; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 1.25.40.770; TAF6, C-terminal HEAT repeat domain; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037796; TAF6.
DR InterPro; IPR011442; TAF6_C.
DR InterPro; IPR046344; TAF6_C_sf.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10221; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6; 1.
DR PANTHER; PTHR10221:SF9; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6; 1.
DR Pfam; PF02969; TAF; 1.
DR Pfam; PF07571; TAF6_C; 1.
DR SMART; SM00803; TAF; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002899};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 9..85
FT /note="TATA box binding protein associated factor (TAF)
FT histone-like fold"
FT /evidence="ECO:0000259|SMART:SM00803"
SQ SEQUENCE 614 AA; 70025 MW; 0442F028D4427CD8 CRC64;
MFSRESDNVS IPSEFIISLA KTHGFMQSGK VDLQTVSARI IADTVEFRIK QIIQEASKFM
YRNARTTNHM ALTSDDIRCA LKSLKMQDLP GYSDLCNHRY VCADKLYMGN RVIKRESKLK
STKDNWGRCK LSDIVYNDMG TLASPVPSLS VHWLSVKGTL PLVSSHFGVD VTDKLSRRAE
EAVALIGDSS KMRKNENIEN FSLTNNLLLK TRNNNIITRL SNAFTDSMNN SIARATNTAN
EPTTYIPRVE HVLEKEHHFF LNCVKNAITR AIDLGVIHTS QYKQLDKVLH ILSTSLALDQ
LMPELSYFFA TQMDIHMKNS LPHAVSIMLS FAYALISNPH AHIHFHIHQL LIPIIQVAIG
KCEFPIVLIY QILRLRKKAA NLVGKIAFVL RSSRNGLEFI DSQLILLLKQ ALSADEISIF
TLYGSIACLS NMSPISRSLL LYPNFNSILS TLIYLSISTR HSLDIDNIPT QHFQHSYDEH
NNIHHTLCKK DNFQLIQTKN TIYNETIQLL LGTMYYSLEN DFLNMPDLFF SSSNSGYSPP
FYQPNIKQLL EILSTFKLFM NGLLYDLFTP FLSAILRKFI HYFRNHSLGS LKMVYHTKYE
KLDLATGHLI ELTL
//
