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Database: UniProt
Entry: A0A1N6MY28_9GAMM
LinkDB: A0A1N6MY28_9GAMM
Original site: A0A1N6MY28_9GAMM 
ID   A0A1N6MY28_9GAMM        Unreviewed;       267 AA.
AC   A0A1N6MY28;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE            EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN   ORFNames=XIS1_460037 {ECO:0000313|EMBL:SIP73722.1};
OS   Xenorhabdus innexi.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=290109 {ECO:0000313|EMBL:SIP73722.1, ECO:0000313|Proteomes:UP000196435};
RN   [1] {ECO:0000313|Proteomes:UP000196435}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HGB1681 (deposited as PTA-6826 in the American Type Culture
RC   Collection) {ECO:0000313|Proteomes:UP000196435};
RA   Gaudriault S.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004953}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC       biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00025705}.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005879, ECO:0000256|RuleBase:RU003960}.
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DR   EMBL; FTLG01000188; SIP73722.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1N6MY28; -.
DR   OrthoDB; 9815856at2; -.
DR   UniPathway; UPA00262; UER00211.
DR   Proteomes; UP000196435; Unassembled WGS sequence.
DR   GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd11642; SUMT; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006366; CobA/CysG_C.
DR   InterPro; IPR003043; Uropor_MeTrfase_CS.
DR   NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR   PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR   PROSITE; PS00839; SUMT_1; 1.
DR   PROSITE; PS00840; SUMT_2; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000256|RuleBase:RU003960};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196435};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT   DOMAIN          6..216
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
SQ   SEQUENCE   267 AA;  28674 MW;  819C20D5626F0389 CRC64;
     MNKGCVWLVG AGPGDAGLIT VKGLQCIQAA DVIVHDRLVN PELIAQIPDC CEIINVGKEH
     DYHPIPQNTI NQILIKQALA GKQVVRLKGG DPYVFGRGGE EAEVLAQYGI KFEIVPGISS
     SIGGLAYAGI PVTHRNYASG FHIVTGHTSQ ENKQQNWKIL AQLEGTLIIL MGMTRLAEIC
     QQLVQHGKPA TTPAAVVMYA SHAEQESVIG TLETLAVKTA ERELHAPALI VIGDVVNLSE
     KLCFSPSYCD LPSLFPMSEN YIDGAIS
//
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