ID A0A1N6MZJ7_9GAMM Unreviewed; 1485 AA.
AC A0A1N6MZJ7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Chromosome partition protein MukB {ECO:0000256|HAMAP-Rule:MF_01800};
DE AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000256|HAMAP-Rule:MF_01800};
GN Name=mukB {ECO:0000256|HAMAP-Rule:MF_01800,
GN ECO:0000313|EMBL:SIP74255.1};
GN ORFNames=XIS1_600021 {ECO:0000313|EMBL:SIP74255.1};
OS Xenorhabdus innexi.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=290109 {ECO:0000313|EMBL:SIP74255.1, ECO:0000313|Proteomes:UP000196435};
RN [1] {ECO:0000313|Proteomes:UP000196435}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGB1681 (deposited as PTA-6826 in the American Type Culture
RC Collection) {ECO:0000313|Proteomes:UP000196435};
RA Gaudriault S.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC and cell cycle progression. Functions as a homodimer, which is
CC essential for chromosome partition. Involved in negative DNA
CC supercoiling in vivo, and by this means organize and compact
CC chromosomes. May achieve or facilitate chromosome segregation by
CC condensation DNA from both sides of a centrally located replisome
CC during cell division. {ECO:0000256|HAMAP-Rule:MF_01800}.
CC -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC terminal region. Interacts, and probably forms a ternary complex, with
CC MukE and MukF via its C-terminal region. The complex formation is
CC stimulated by calcium or magnesium. Interacts with tubulin-related
CC protein FtsZ. {ECO:0000256|HAMAP-Rule:MF_01800}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000256|HAMAP-
CC Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC {ECO:0000256|HAMAP-Rule:MF_01800}.
CC -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC coiled coil regions, allows the homodimerization, forming a V-shaped
CC homodimer. {ECO:0000256|HAMAP-Rule:MF_01800}.
CC -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01800}.
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DR EMBL; FTLG01000204; SIP74255.1; -; Genomic_DNA.
DR OrthoDB; 6722439at2; -.
DR Proteomes; UP000196435; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.850; -; 1.
DR Gene3D; 3.40.1140.10; -; 2.
DR Gene3D; 1.20.5.420; Immunoglobulin FC, subunit C; 1.
DR Gene3D; 3.30.70.3500; MukB, hinge domain; 1.
DR HAMAP; MF_01800; MukB; 1.
DR InterPro; IPR012090; MukB.
DR InterPro; IPR032520; MukB_hinge.
DR InterPro; IPR042501; MukB_hinge_sf.
DR InterPro; IPR007406; MukB_N_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR42963; CHROMOSOME PARTITION PROTEIN MUKB; 1.
DR PANTHER; PTHR42963:SF1; CHROMOSOME PARTITION PROTEIN MUKB; 1.
DR Pfam; PF04310; MukB; 1.
DR Pfam; PF16330; MukB_hinge; 1.
DR Pfam; PF13558; SbcC_Walker_B; 1.
DR PIRSF; PIRSF005246; MukB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01800}; Cell cycle {ECO:0000256|HAMAP-Rule:MF_01800};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_01800};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP-
KW Rule:MF_01800}; Coiled coil {ECO:0000256|HAMAP-Rule:MF_01800};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01800};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067, ECO:0000256|HAMAP-
KW Rule:MF_01800};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01800};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01800}; Reference proteome {ECO:0000313|Proteomes:UP000196435}.
FT DOMAIN 2..227
FT /note="MukB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04310"
FT DOMAIN 645..810
FT /note="MukB hinge"
FT /evidence="ECO:0000259|Pfam:PF16330"
FT REGION 666..783
FT /note="Flexible hinge"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01800"
FT REGION 993..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 343..464
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01800"
FT COILED 515..600
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01800"
FT COILED 838..865
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01800"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01800"
SQ SEQUENCE 1485 AA; 170824 MW; FFAB4AA624CA976B CRC64;
MIERGKFRSL TLVNWNGFFA RTFDLDELVT TLSGGNGAGK STTMAAFVTA LIPDLTLLHF
RNTTEAGATS GSRDKGLHGK LRAGVCYSTL DVVNSRHQRV IAGVRLQQIA GRDRKVDIKP
FMIQGVPASI QPTQLLTENI NERQARVLPL NELKERLEEM DGVQFKQFNS ITDYHSLMFD
LGVIPKRLRS ASDRSKFYRL IEASLYGGIS SAITRSLRDY LLPENSGVRK AFQDMEAALR
ENRVTLEAIR VTQSDRDLFK HLITEATAYV SADYMRHANE RRVHLDEALA LRSELFGSRR
QLVTEQYRHV EMARELTEQS GASSDLEMDY QAASDHLNLV QTAMRQQEKI DRYQADIEEL
TYRLEEQTEV VEEAKEMQAE YEAASEAAEQ EVDELKSQLA DYQQALDVQQ TRAIQYQQAL
QALERARELC QLPELSAENA DEWQETYQAK EQQATETLLA LEQKLSVADA AHSQFEQAYQ
LVKNIVGEVS RSEAWHRARE VLREWSSQRH LAERVQPLRI QLAELEQRLN SQQNAERMLE
EFCKRHHQQY QAEDLEVLQG ELEAQLEELS LTANESGESR MQVRQELEQL RQKIQTLTAR
APVWLAAQET LDQLCEQSGE TFEDSNDVTE YMQQLLEQER ETTVERDNVS AQKRELEKQI
ERLSQPSGAE DSRLLALAER FGGVLLSEIY DDITIDDAPY FSALYGSARH AIVVPDLSLV
RPHLEALEDC PEDLYLIEGD PQSFDDSVFD FEEQENAVLV KSSDRQWRYS RYPEVPLFGR
AARENRLEAL GLERDTLAER YATLSFDVQK IQRAHQAFSR FVGKHLSVAF DSDPEMEIRS
LNQRRTELER ELSQFESHTQ QNQQKLTQVK ESLSVLNRLI PQIAILLDET LIDRVEAVRE
EMSEAQDAAR FLQQHTNTLN KLEPMVSVLQ SDPRQHEQLQ RDYELVKQSQ IKAKQQAFAL
TEVVQRRVHF SYSDSAGMLS ENSDLNDKLR QRLEHAESDR SRAREQLRQQ QSQSAQFSQV
LASLKSSYDT KQDMLKELEQ EMKDIGVQAD ANAENRARER RDQLYASVQA NRSRINQLEK
QIAFCEAEME NLQKKLRKSE RDYYQKREQV VSSKAGWCAV MRMVKDNGVE RRLHRRELAY
MDADALRSMS DKALGALRLA VADNEHLRDA LRLSEDPKRP ERKIQFFVAV YQHLRERIRQ
DIIRTDDPVD AIEQMEIELA RLTEELTARE QKLAISSKSV ANIIRKTIQR EQNRIRMLNQ
GLQMVSFGQV GGVRLNVNIR ESHAALLDVL SEQQEQHQDL FNSQRLTFSE AIAKLYQRLN
PQIDMGQRLP QTIGEELLDY RNYLELDVEV NRGSDGWLKA ESGALSTGEA IGTGMSILVM
VVQSWEEESR RLRGKDISPC RLLFLDEAAR LDAKSIATLF ELCERLQMQL IIAAPENISP
EKGTTYKLVR KIFNNQEHVH VVGLRGFGQE TPVIEQRQEQ AQAIF
//