ID A0A1N6PFD0_9GAMM Unreviewed; 855 AA.
AC A0A1N6PFD0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05421546_0595 {ECO:0000313|EMBL:SIQ03078.1};
OS Lysobacter tolerans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Lysobacter.
OX NCBI_TaxID=1604334 {ECO:0000313|EMBL:SIQ03078.1, ECO:0000313|Proteomes:UP000241788};
RN [1] {ECO:0000313|EMBL:SIQ03078.1, ECO:0000313|Proteomes:UP000241788}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UM1 {ECO:0000313|EMBL:SIQ03078.1,
RC ECO:0000313|Proteomes:UP000241788};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FTLW01000001; SIQ03078.1; -; Genomic_DNA.
DR RefSeq; WP_076585073.1; NZ_FTLW01000001.1.
DR AlphaFoldDB; A0A1N6PFD0; -.
DR STRING; 1604334.SAMN05421546_0595; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000241788; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 687..703
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 855 AA; 94163 MW; 1EF22E130A1527B3 CRC64;
MSSLDQHTPL MRQFFTAKAE HPDVLLFFRM GDFYELFYDD ARKAAKLLDL TLTQRGQSAG
QPIPMAGVPH HAYEGYLARL VALGESVAIC EQVGDPATSK GLVERKVVRI VTPGTVTDEA
LLQDRRDTLL MAVARGKQGF GLAWADLAGG RFQVAQVENE DQLEAELARL EPAELLLPDE
GEWPASLMTR NGVRRRAPWL FDVDSSRRKL LAFFNVHDLT GFGIDGLPMA IAAAGALLGY
VEETQKQQLP HLTAITLETG DAAIAMNAAT RRHLELDTRV DGDTKHTLLG VLDSTITPMG
GRLLRRWLHR PLRTRDTVEP RLHSVQMMLD ARSFEDLRET FRGFGDVERI LTRVALRSAR
PRDLSTLRDA LLKLPDLRAL LAPLDSPRLQ WLSDTLGEHV GTAGLLQRAI IEQPPLLARD
GGVIKEGFDA ELDELRRLST NADQFLIDLE AREREATGIN TLKVGYNRVH GYYIEMGKMH
AGKVPVHYTR RQTLANAERY ITEELKSFED KVLSARERSL AREKGLYEDV LDALNEDLQP
LRQCAEALAE LDVLCGFAER AEALDWSRPK LLSDAVLQIE GGRHPVVEAV RSEPFTPNDL
MLDDATRMLV ITGPNMGGKS TYMRQNALIV LLAHIGSFVP ATRAEIGPID RILTRIGAGD
DLAKGQSTFM VEMSETSYIL HHATSQSLVL MDEIGRGTST YDGLALAEAC ARHLAASNRS
YTLFATHYFE LTALATTGSG IRNVHLDAVE HGDALVFMHA VKDGPADRSF GLQVASLAGL
PKPVVREARA RLAELEQQGG AKSPPLTAQV LDSPQQIGLF APPSAAMEAL AGIDPDELTP
KQALEALYRL KSLSN
//
