ID A0A1N6QAN1_9SPIO Unreviewed; 562 AA.
AC A0A1N6QAN1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN ORFNames=SAMN05920897_10482 {ECO:0000313|EMBL:SIQ13578.1};
OS Alkalispirochaeta americana.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Spirochaetaceae;
OC Alkalispirochaeta.
OX NCBI_TaxID=159291 {ECO:0000313|EMBL:SIQ13578.1, ECO:0000313|Proteomes:UP000186400};
RN [1] {ECO:0000313|EMBL:SIQ13578.1, ECO:0000313|Proteomes:UP000186400}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ASpG1 {ECO:0000313|EMBL:SIQ13578.1,
RC ECO:0000313|Proteomes:UP000186400};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:43474; EC=3.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000926};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; FTMS01000004; SIQ13578.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1N6QAN1; -.
DR STRING; 159291.SAMN05920897_10482; -.
DR Proteomes; UP000186400; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd02205; CBS_pair_SF; 1.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR InterPro; IPR010766; DRTGG.
DR InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF02833; DHHA2; 1.
DR Pfam; PF07085; DRTGG; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01131; DHHA2; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR PROSITE; PS51371; CBS; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186400}.
FT DOMAIN 268..329
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 562 AA; 62191 MW; 3D1AAB65705CB26D CRC64;
MIVLDFYKIL NMRRTTLERV FVAGHKNPDM DSTCAAHCYA ALKQRLNPGF TYLPIRSGPL
SDQIQEVFAQ AGISVPPHYD TIAPTVGLVA RRSPVLIAPD DPVLEVFNAV KIRTISSVPV
IAQDSTFAAM VGVNEITSYV ASQNQEHRPI YTFLVENFEK VLPGTLLQRG AQNRFDASLV
TSAMPVEQSL KRLKRMESPP LLVVGHIPEI IACAVKNQFP AIVLTGITSP REIEKLIKGY
KGSVFLSETD TAESIRMLRL SSPVSTIMDT QVPRLQADMP FDEAKALLLS SSYRGLPVFE
GEEFIGIVSR RSFIERPRPK LIMVDHNELS QAVDGAEQAE LLEIVDHHRL APPSTNSPIE
VTTRVVGSTC TLIYEEFSAR GFAIEPDIAL LLLSGIISDT VNLQSPTTTE ADRRAILRLE
TITSISAAEH AQKLFAQIKA LGQREPQEII LSDFKLYEQK GIPFGIGQVE VTTLSDSASY
RDRLLQALED VANQKRIDWA MLMVTDVIKR DSLLLSSGYP AGETLLPFRK QAERTFDLSG
VLSRKKQLLP EIMRVLSKAG AQ
//
