ID   A0A1N6TZN0_9ACTN        Unreviewed;       624 AA.
AC   A0A1N6TZN0;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Serine protease, subtilisin family {ECO:0000313|EMBL:SIQ58784.1};
GN   ORFNames=SAMN05444858_103159 {ECO:0000313|EMBL:SIQ58784.1};
OS   Micromonospora avicenniae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=1198245 {ECO:0000313|EMBL:SIQ58784.1, ECO:0000313|Proteomes:UP000186004};
RN   [1] {ECO:0000313|EMBL:SIQ58784.1, ECO:0000313|Proteomes:UP000186004}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45758 {ECO:0000313|EMBL:SIQ58784.1,
RC   ECO:0000313|Proteomes:UP000186004};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
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DR   EMBL; FTNF01000003; SIQ58784.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1N6TZN0; -.
DR   STRING; 1198245.SAMN05444858_103159; -.
DR   OrthoDB; 9798386at2; -.
DR   Proteomes; UP000186004; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000186004};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..624
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013065828"
FT   DOMAIN          503..624
FT                   /note="P/Homo B"
FT                   /evidence="ECO:0000259|PROSITE:PS51829"
FT   REGION          407..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        156
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        188
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        345
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   624 AA;  62316 MW;  0348F7DCB0747C5D CRC64;
     MGLAHRSVLV GVATLSMLAA ATPALAAEPT GTIRSAGGDT AVADSYIVVF KDTAVGQAAV
     GDNADRLVGR HGGSVARTYG AALRGFEARV DAKAAARIAA DPAVAYVEQN HTVSIADTQP
     NPPSWGLDRI DQRNLPLNSS YTYPNTASNV RAYIIDTGIR FTHNDFGGRA VSGYDAIDGG
     AADDCNGHGT HVAGTVGGSA YGVAKGVQLV GVRVLNCQGS GTNAQVVAGI DWVTANAVKP
     AVANMSLGGS ANSAIDTAVT NSINSGITYA VAAGNGDVFG NRQNACNYSP ARVGPAITVG
     ATQNNDSAAS FSNYGTCVDI LAPGVNITSA WYTSNTATNT ISGTSMASPH VAGVAALVLS
     ATPGLTPQQV RDSLVNNSTP NVLTNLGTGT PNRLLYVVNG STPPPTNDFS VSVSPTSGST
     APGGSVTATV GTATTSGSAQ SVSLSASGLP SGATASFSPS TVTSGGSATL TIATAASTPA
     GSYPVTITGT GASATRTATY TLTVTGTSGG CSGTNGTDVA IPDTGATVSS SIVISGCGRN
     ASASSQVPVN IVHTFRGDLV IDLVAPDGSA YRLKNSSFFD GADNVNTTYT VNLSSEAANG
     TWQLRVRDVY SGDTGYLNTW SLNL
//