ID   A0A1N6WVY9_9ACTN        Unreviewed;       827 AA.
AC   A0A1N6WVY9;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=SAMN05444858_105126 {ECO:0000313|EMBL:SIQ94181.1};
OS   Micromonospora avicenniae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=1198245 {ECO:0000313|EMBL:SIQ94181.1, ECO:0000313|Proteomes:UP000186004};
RN   [1] {ECO:0000313|EMBL:SIQ94181.1, ECO:0000313|Proteomes:UP000186004}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45758 {ECO:0000313|EMBL:SIQ94181.1,
RC   ECO:0000313|Proteomes:UP000186004};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FTNF01000005; SIQ94181.1; -; Genomic_DNA.
DR   RefSeq; WP_076470083.1; NZ_FTNF01000005.1.
DR   AlphaFoldDB; A0A1N6WVY9; -.
DR   STRING; 1198245.SAMN05444858_105126; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000186004; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186004};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          24..480
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
SQ   SEQUENCE   827 AA;  88894 MW;  CD41AF02F8633CF1 CRC64;
     MARRKETKVD LSAFDQAGAR VFDNPLVTEV SDSYLEYAFS VIHSRALPDA RDGLKPVHRR
     ILWSMYEQGH RPDRGHVKSA RIVGDVMGKY HPHGDAAIYD AMVRLAQDFS LNAPLIDGHG
     NFGSPDDGPA AARYTEARMS REAMLLVGEL GEDTVDVEPN YDGSLTQPTV LPAAFPNLLV
     NGASGIAVGM ATNMIPHNLA EVVQAARWLI NHPDASLDKL MEFVPGPDLP TGGMLLGLDE
     VRRAYETGRG VVRMRAKVEI GPLEGSRGRQ AITVVELPYG VGAEKVIAAI TNEVTKTKRL
     SGIADVKDLT DRESGTRLVV ECKVGVNPQA LLADLYRLTP LEQSFGVNNL VLVDGQPQTL
     GLKALLEVFL AHRYEVVTRR SSYRRRKREE RLHLVDGLLI ALLDIDKVVK LIRGSEDAQA
     AKDALMQKFK LSEIQATYIL DTPLRRLTKY DRLELEAEQE KLRGEIAELS KILDDPKVLR
     KLVSDELAAV VKQFASPRRT TLIDGDLKEV LAASAPAGPL EVADDPCQVI LSATGLVART
     AAESEETAEV RRRHGRVKHD VVRASVPSTA RGRVLLVTSA GRAFKIDVLP LPVLPEQAGT
     LSLRGGMSAA ELVPLEPGET VVGLAPLGAA AEGSPGLALG TRQGVVKVCA PEWPVRADEF
     EVIGLREGDE VVGATWLTDG AEALTFLTSE ASLLRFPATL VRPQGIRGGG MAGINLPGTA
     QVVFFGAVRT DDPTHGEPMV VTSTGATVKV TPFAAYPAKG RATGGVRAHR FLKGETDVVV
     GWVGPRPVGS TANGEPVELP AADPRRDGSG FAVMLGPTVV GHQIERD
//