ID A0A1N6XB98_9BACT Unreviewed; 479 AA.
AC A0A1N6XB98;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05421545_2041 {ECO:0000313|EMBL:SIQ99521.1};
OS Pontibacter lucknowensis.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Pontibacter.
OX NCBI_TaxID=1077936 {ECO:0000313|EMBL:SIQ99521.1, ECO:0000313|Proteomes:UP000185924};
RN [1] {ECO:0000313|Proteomes:UP000185924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DM9 {ECO:0000313|Proteomes:UP000185924};
RA Varghese N., Submissions S.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; FTNM01000002; SIQ99521.1; -; Genomic_DNA.
DR RefSeq; WP_076421983.1; NZ_FTNM01000002.1.
DR AlphaFoldDB; A0A1N6XB98; -.
DR STRING; 1077936.SAMN05421545_2041; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000185924; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF4; TYPE I RESTRICTION ENZYME ECOKI METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000185924};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..131
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 141..442
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 479 AA; 54458 MW; 9AD9985094E29858 CRC64;
MSNLSGIIKS IRDIMRQDAG VDGDAQRISQ MVWMLFLKVF SDKEEEWELT IDNYKSPIPA
RLQWSNWAAD EEGMTGDELL DFVNNELFET LKNLDVVPKT DPQGWIVKQV FEDTYNYMKS
GTLIRQVINK INQIDFNSSS DRHLFNDIYE NMLKELQSAG SSGEYYTPRA VTQFMVDMTA
PQIGESVLDP ACGTGGFLTC AIEHVRTQLN NPSDIQTLQE SFQGVEKKPL PHMLATTNLM
LHGMDVPVIR HDNLLVRPYD SWGPKDQVDI ILSNPPFGGT EEEGTDANFP PKFKTKETAD
LFMALIMRLL KDNGRAAVVL PDGTLFGEGV KTRIKEELLS KCNLHTLVRL PNGVFNPYTS
IKTNLLFFTK GQPTKEVWYF EHPYPAGAKS YNKGKPINIK EFDLEKAWWH NREENEYAWR
VPVEEIVARN YNLDIKNPHA PETALGDPNE LLAQLQQTAQ RVKALQQEIV NALEESLLS
//
