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Database: UniProt
Entry: A0A1N6XNE5_9GAMM
LinkDB: A0A1N6XNE5_9GAMM
Original site: A0A1N6XNE5_9GAMM 
ID   A0A1N6XNE5_9GAMM        Unreviewed;       432 AA.
AC   A0A1N6XNE5;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   16-JAN-2019, entry version 14.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=SAMN05421840_107190 {ECO:0000313|EMBL:SIR03874.1};
OS   Shewanella morhuae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=365591 {ECO:0000313|EMBL:SIR03874.1, ECO:0000313|Proteomes:UP000185718};
RN   [1] {ECO:0000313|EMBL:SIR03874.1, ECO:0000313|Proteomes:UP000185718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1205 {ECO:0000313|EMBL:SIR03874.1,
RC   ECO:0000313|Proteomes:UP000185718};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
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DR   EMBL; FTNN01000007; SIR03874.1; -; Genomic_DNA.
DR   RefSeq; WP_076499446.1; NZ_FTNN01000007.1.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000185718; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000185718};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:SIR03874.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138}.
FT   DOMAIN      109    320       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   432 AA;  45615 MW;  83A56207BDCFF166 CRC64;
     MKVLIIGGGG REHALAWKAA QSAQVETVYV APGNAGTALE PNVENLAISA TDIPALLAFA
     QTNNIELTIV GPEAPLVMGV VDAFNAAGLA IFGPTKAAAQ LEGSKAFTKD FLARHNIPTA
     GYKNCTDIND AKAFVRELTA TTGYPVVIKA DGLAAGKGVI IALNQAEADA AIDDMLAGNK
     FGDAGSRVVI EEFLKGEEAS FIVMVDGKNI LPMATSQDHK ARDNGDYGPN TGGMGAYSPA
     PVVTQAVHDW TINNVIRPTV DGMAAEGNVY TGFLYAGLMI SPDGSAKVLE YNCRFGDPET
     QPIMMRLQSD IVELCLAATR GELNKVTAEY DERAAVGVVL AAGGYPDEYR KFDVIDGLSL
     GDNNGKVFHA GTEIKDGHVV TNGGRVLCAT ALGNTVTEAQ KAAYKLVDEI HWDDVYFRTD
     IGYRAIAREQ QG
//
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