ID A0A1N7AZS7_9FIRM Unreviewed; 819 AA.
AC A0A1N7AZS7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=CRISPR-associated helicase, Cas3 family {ECO:0000313|EMBL:SIR44532.1};
GN ORFNames=SAMN05421834_1275 {ECO:0000313|EMBL:SIR44532.1};
OS Halanaerobium kushneri.
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=56779 {ECO:0000313|EMBL:SIR44532.1, ECO:0000313|Proteomes:UP000185669};
RN [1] {ECO:0000313|Proteomes:UP000185669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700103 {ECO:0000313|Proteomes:UP000185669};
RA Varghese N., Submissions S.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; FTNC01000027; SIR44532.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1N7AZS7; -.
DR STRING; 56779.SAMN05421834_1275; -.
DR Proteomes; UP000185669; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR Pfam; PF18019; Cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 3..215
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 277..476
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 498..696
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 819 AA; 96876 MW; 3E599ECC02011E44 CRC64;
MIYSHPDKLL IDHLNNVYKL GKEIFLRKKL NFDNQEEIEK ALAIILLAHD FGKATDYFQQ
KLKESSQNNA ESSKQIEFNL ELSKHSHISA LLAYQFAEQI LEDKTLVWIV FINIYRHHSN
FKDLDIMLKF DDSDWLKLEK QFRSLDLNEL DKITAEISDF DFKPSSIDFD ELKNNFTNWR
FRKKLRTFKN NSSKDFNYYL ISNLLFSILI FADKAEAIFY SKGYSFEDLK KVTLNRKNLP
GDLVDNYRKI KGWDQADSKI NQRRNEIYDE VIDQVENLNF KDERILSVNV PTGAGKTISV
LSAALKLRNR TFQDFRIIYA LPFTSIIDQN YDVFLDVLNH STIKADSTSI IKHHYLNAKE
YYFNEEEKES QKLDYDIARH LIESWQSEIV VTTFVQLLHS IFSNRNRSLI KFNNISNSII
ILDEVQNIPH KYWKLIKEFL SDMAEKLNCY FIFLTATMPL IYNENKKEIK ELAISKKEHF
NFFDRINLDT SMFDQSLTVD QFKDYIEEEL IEFNNQGFLI ILNTIKSSIE LYNHIEKLIS
EEVIEGDLIY LSTNIIPKER QKRINEIGKQ RRQIIVSTQM VEAGVDIDLD RVYRDFAPLD
SINQSCGRCN RNFDPDSKGI VKLIRLINEN HNNKEYASYI YDGFLLKITS DIITELPDIV
GEKYFFEMNQ KYFNKIDQLK SDDNSEALIS KIKNLKYEKS FFKDEKGEIF RLIADDYNTV
NLFMAADEES QELWEDYKEI SALESNNIED FMNKKSKFEN IKKEFLSYVI TIPKFTAEKH
IEDEQLKNNF NYISPFQIED VYNLSTGFKR GKIERETFF
//
