ID A0A1N7DMU9_9NOCA Unreviewed; 1409 AA.
AC A0A1N7DMU9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Sulfite reductase (NADPH) alpha subunit {ECO:0000313|EMBL:SIR77147.1};
GN ORFNames=SAMN05445060_0771 {ECO:0000313|EMBL:SIR77147.1};
OS Williamsia sterculiae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Williamsia.
OX NCBI_TaxID=1344003 {ECO:0000313|EMBL:SIR77147.1, ECO:0000313|Proteomes:UP000186218};
RN [1] {ECO:0000313|EMBL:SIR77147.1, ECO:0000313|Proteomes:UP000186218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CPCC 203464 {ECO:0000313|EMBL:SIR77147.1,
RC ECO:0000313|Proteomes:UP000186218};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Nitrogen metabolism. {ECO:0000256|ARBA:ARBA00004909}.
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. NasA/NapA/NarB subfamily.
CC {ECO:0000256|ARBA:ARBA00008747}.
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DR EMBL; FTNT01000002; SIR77147.1; -; Genomic_DNA.
DR STRING; 1344003.SAMN05445060_0771; -.
DR Proteomes; UP000186218; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR CDD; cd02791; MopB_CT_Nitrate-R-NapA-like; 1.
DR CDD; cd02754; MopB_Nitrate-R-NapA-like; 1.
DR CDD; cd06199; SiR; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041957; CT_Nitrate-R-NapA-like.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR43105:SF9; NITRATE REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15190)-RELATED; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Molybdenum {ECO:0000256|ARBA:ARBA00022505};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000186218};
KW Transport {ECO:0000256|ARBA:ARBA00022982}.
FT DOMAIN 17..78
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
FT DOMAIN 848..985
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 1045..1258
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT REGION 984..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1409 AA; 152229 MW; 1C24C9E84FFB29D0 CRC64;
MATLVGVVPE AAAPADTRVT RTACSYCGVG CGIEVTTRVE PGRGPVIAKV SGDKLHPTNH
GRLCTKGATH AELMRADEQR MRSAYLRPAR GRPAQAVAVD TAVGEVATRM RAIIDEHGPN
AVAVYVSGQM STEAQYLATK LAKGYLRTTH IESNSRLCMA SAGTGYKQSF GSDGPPGSYQ
DFDKADLFLV IGSNMADCHP ILYLRMVDRL KQGAKLIVVD PRRTTTADRA DLYLPVRPGS
DLALLNGLLH LLVESGDIDE EFIAAHTEGW EQMPGFLADY PPERVAELTG LSCDDIRTAA
GMIADAGEWM SCWTMGLNQS THGTWNTNAI NNLHMATGAL CRPGSGPLSL TGQPNAMGGR
EMGYMGPGLP GQRVVTSEDD RRFCEQRWGL DAGTIRSDVG PGTIEMFSQM ASGDIKACWI
ICTNPVASVA NRRTVIAGLE AAELVVVQDA YTDTATAEYA DVLLPAALWA ESDQVMINSE
RNVTLLQQST QPLGEAKPDW QLIAEVATAL GFGEAFAHTS ASEVFDEITE FWNPRTGWDL
RGVDHDRLRS TPLQWPCPPP GEPGGDDDRH PIRYLNDGVS QTLFTDDDGT VPELAFATPS
RRAQFLPRPH MDPAELPDDE YPMVLNTGRL QHQWHTMTKT GKVAKLNKLN PSPFVEIHPD
DAERLGIRDE HEVEIASRRG RAVFPAVITD RVRPGNCFTP FHWNDEHGEY LTVNAVTNDA
VDPVSLQPEF KACAVSLRPV AARPEPEVTD VDAHPLAAAL GVPQTVPELD EGEKAYVGGF
LAGVQSRGGQ VSDGTVATVP VLPPSAPVRG VVRMWVDGML AGMYSGAAGA VDDPVVEKGA
GQGADGSLIV LWASQTGGAE EFAGTVEGAL TAAGYAPRLV EMDGCGLDQL AAASRVVVVT
STFGDGGPPD DAADFWERLS SATPDLGGVS FAVLGMGDSS YDDFCGFAAK VDDRFAELGA
RRLTDIVRCE PDETDRADEW LQRLTPLVDG GEGVSSSGDR DRDDAVSPEV APPHPGGGGG
GSVTVTEPRV QTAGVEAPAS VFTRANPVHA LLVRNTVLTG AGSQKEVRTF GFDLADHDVE
YEAGDSLGVM PTNSTQHVDA FLVAAGLDGD VAVDGTTSMR EALRTRHDIC RLTPGLLKFV
AERSGNGQLA TLLRRDNKNE LAKWMWGRHA VDLLRAFPIE ATPTEWTETL GGLQPRQYSI
SSSPRESPQE VQLTVSVVRY DGDDGTPRGG VCSTFLADRA DDAGVPIFLN RSPHFRPPAD
PGTPMIMIGP GTGIAPFRGF LHERRALGHR GDNWLFFGDQ HAADNFYYRS ELEDMFRDGF
LTRLDVAFSR DQRERIYVQD RMVEHGALLW RWLESGAHFY VCGDATRMAR DVDETLLGII
SHHGRMGEDE AKAYRKELVA TKRYVRDVY
//
