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Entry: A0A1N7DS88_9ACTN
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ID   A0A1N7DS88_9ACTN        Unreviewed;       356 AA.
AC   A0A1N7DS88;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=SAMN05445060_0861 {ECO:0000313|EMBL:SIR78638.1};
OS   Williamsia sterculiae.
OC   Bacteria; Actinobacteria; Corynebacteriales; Williamsiaceae;
OC   Williamsia.
OX   NCBI_TaxID=1344003 {ECO:0000313|EMBL:SIR78638.1, ECO:0000313|Proteomes:UP000186218};
RN   [1] {ECO:0000313|EMBL:SIR78638.1, ECO:0000313|Proteomes:UP000186218}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CPCC 203464 {ECO:0000313|EMBL:SIR78638.1,
RC   ECO:0000313|Proteomes:UP000186218};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; FTNT01000002; SIR78638.1; -; Genomic_DNA.
DR   RefSeq; WP_076476879.1; NZ_FTNT01000002.1.
DR   BioCyc; GCF_900156495:BW971_RS04245-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000186218; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000186218};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186218};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       51    350       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   356 AA;  37631 MW;  1D53EA6B5E4FBB74 CRC64;
     MSVSSSTTIV TTSDRRITAF REIPSPSIIR SELPLTSRRA LAVQRDRDEI AAILAGTDDR
     LLVVVGPCSV HDPIAALDYA RRLAALTAEY ADRLKIVMRV YFEKPRTTVG WKGLINDPGM
     DGSFDVERGL RTARSLLLDV IDLGLPVGCE FLEPTSPQYI ADAVAWGAIG ARTTESQVHR
     QLASGLSMPV GFKNGTDGTV QVAVDGVRAA AAQHVFFGID DFGHGALVES AGNPDCHVIL
     RGGTPGPNHD DASVLAAVAA LDEAGLTGRV MVDCSHANSG KDHVRQAAVA GEVAASIRAR
     RAAGRAGVIS GVMLESFLEA GAQDVDARPL VYGKSVTDKC MSWDTTTEVL ADLARC
//
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