ID   A0A1N7EWU6_9GAMM        Unreviewed;       894 AA.
AC   A0A1N7EWU6;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=23S rRNA (Guanine2445-N2)-methyltransferase / 23S rRNA (Guanine2069-N7)-methyltransferase {ECO:0000313|EMBL:SIR92618.1};
GN   ORFNames=SAMN02745664_10821 {ECO:0000313|EMBL:SIR92618.1};
OS   Moraxella cuniculi DSM 21768.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Moraxella.
OX   NCBI_TaxID=1122245 {ECO:0000313|EMBL:SIR92618.1, ECO:0000313|Proteomes:UP000187495};
RN   [1] {ECO:0000313|Proteomes:UP000187495}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21768 {ECO:0000313|Proteomes:UP000187495};
RA   Varghese N., Submissions S.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FTNU01000008; SIR92618.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1N7EWU6; -.
DR   Proteomes; UP000187495; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008990; F:rRNA (guanine-N2-)-methyltransferase activity; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd11715; THUMP_AdoMetMT; 1.
DR   Gene3D; 3.30.2130.30; -; 1.
DR   Gene3D; 3.30.750.80; RNA methyltransferase domain (HRMD) like; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR017244; 23SrRNA_methyltr_KL.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR019614; SAM-dep_methyl-trfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR004114; THUMP_dom.
DR   PANTHER; PTHR47313; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L; 1.
DR   PANTHER; PTHR47313:SF1; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L; 1.
DR   Pfam; PF10672; Methyltrans_SAM; 1.
DR   Pfam; PF02926; THUMP; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   PIRSF; PIRSF037618; RNA_Mtase_bacteria_prd; 1.
DR   SMART; SM00981; THUMP; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR   PROSITE; PS00092; N6_MTASE; 1.
DR   PROSITE; PS51165; THUMP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SIR92618.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187495};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SIR92618.1}.
FT   DOMAIN          61..185
FT                   /note="THUMP"
FT                   /evidence="ECO:0000259|PROSITE:PS51165"
FT   REGION          795..855
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          449..476
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        805..825
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        826..849
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   894 AA;  101142 MW;  BC82A7C76028529C CRC64;
     MSLAIPAYFA NLTQFCADDF YIIITCADGL EAALCIELES FELAPQILRA GRVLVRIDLT
     KLYHICLYSR VASRVLLPLG EYHFKQKITD NTEVPDEDIP QALYQFARRI DWTALFGLEH
     RFAVRLSTDK RLTVNQQFAT LRIKDAIADT FNHAFAARPD VDAKSPDFQI FATANQKVAE
     LFLDLSGTSL HRRGYRVANT AAPLKENLAA ALLYECNWHT GEFDAIIDPM CGSGTFISEA
     LLMRAGYPVG IDKASREFGF YAWQHHNESL WLDMVAAAND DFHARLAKLQ QQNLTIVALD
     ADAQAIRACH KNLLAAGLGC LLPSITLQQQ ALHHLPRTLA ALPELAAKNP LIITNPPYGE
     RLGELDFIKP LYQGLGLISA EALRQAGVQQ AYMAVLASQV EQADTLPILS PHTLRCHNGA
     LTVYFRHGEL NLAKLPSLIG DWQKQHIVHE EAQEFVNRLQ KNLSNLKNKA NKYAVSNLRV
     YDADLPNFNV AIDVYGDKIH VQEYAPPKQI PADVAKMRFN LVLQMVREVF GVSRETIFIK
     TRAKQSGNEQ YTKTEHGKRR KLWLAREDGA YFYVNFTDYL DTGLFIDHRT MRGLVKSASR
     GKRVLNLFAY TCSASVHAAL AGAKQVTSVD LSANYLDWGK QNFALNGLLL DAIIEDKGEY
     LPKYQFIAAD VFEWIKHNTE QFEVIFIDPP TFSNSKKFKG TFDVQRDHAA LINRAMNRLS
     ADGVLYFSNN FSKFELDEAL MARYEIVQIT HKTIGFDFNS KKPIHQSYEI RHKNAPVRDF
     VDERVLDKTT RQELMTYQDS KQQDSKQRQG AKRLPQVKES RSKNRPTYPR QANKTQSKQQ
     PSQSGTKRVY INPKAADGAN LAKKLNDKLN IDTQNLSEKR YSIKAKTNTT DKQS
//