ID A0A1N7H4Q6_9ACTN Unreviewed; 429 AA.
AC A0A1N7H4Q6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Coenzyme F420-reducing hydrogenase, alpha subunit {ECO:0000313|EMBL:SIS19847.1};
GN ORFNames=SAMN05421833_13711 {ECO:0000313|EMBL:SIS19847.1};
OS Microbispora rosea.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Microbispora.
OX NCBI_TaxID=58117 {ECO:0000313|EMBL:SIS19847.1, ECO:0000313|Proteomes:UP000186096};
RN [1] {ECO:0000313|EMBL:SIS19847.1, ECO:0000313|Proteomes:UP000186096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12950 {ECO:0000313|EMBL:SIS19847.1,
RC ECO:0000313|Proteomes:UP000186096};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|PIRSR:PIRSR601501-1};
CC -!- COFACTOR:
CC Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC Evidence={ECO:0000256|PIRSR:PIRSR601501-1};
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DR EMBL; FTNI01000037; SIS19847.1; -; Genomic_DNA.
DR RefSeq; WP_076441851.1; NZ_FTNI01000037.1.
DR AlphaFoldDB; A0A1N7H4Q6; -.
DR STRING; 58117.SAMN05421833_13711; -.
DR OrthoDB; 9761717at2; -.
DR Proteomes; UP000186096; Unassembled WGS sequence.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR InterPro; IPR001501; Ni-dep_hyd_lsu.
DR InterPro; IPR029014; NiFe-Hase_large.
DR PANTHER; PTHR43600; COENZYME F420 HYDROGENASE, SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43600:SF2; CYTOSOLIC NIFE-HYDROGENASE, ALPHA SUBUNIT; 1.
DR Pfam; PF00374; NiFeSe_Hases; 2.
DR SUPFAM; SSF56762; HydB/Nqo4-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|PIRSR:PIRSR601501-1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR601501-1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601501-1};
KW Nickel {ECO:0000256|PIRSR:PIRSR601501-1}.
FT BINDING 44
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 63
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 66
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 66
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 370
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 414
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 417
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 420
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
SQ SEQUENCE 429 AA; 47048 MW; FD104F4E53CD56CB CRC64;
MTHKTITVGG LSRVEGEGAL LVRARDGRIE DLELRIYEPP RFFEALLRGR SYTEPPDITA
RICGICPVAY QMSACQAIEA ACGVEVTGPL RDLRLLLYYG EWIESHTLHV YLLHAPDFLG
YDSGIAMAAD HRDLIQQGLA LKKAGNDLVA AIGGRPIHPV NVRVGGFYRV PSRRELAPAA
ERLRRAREIA LRTVSWVAGF DFPDVEHGYR FLALRHPGEY AILSGALITS DGGSFGVREW
PEHVIEEQVP HSTALHARLD GSPGYLVGPM ARYSLNSAQL SPLAREAAAA AGLGPACRNP
FLSIVVRAVE IVHACDEALR IIDDLAEPDA PYVPVEPRAA TGHGASEAPR GTLYHRYRID
ADGLIGEADI VPPTSQNQAR IEADLRHLIE PRLDLPEEEL ATLCERAIRN HDPCISCSAH
FLHLHVDSR
//
