ID A0A1N7HLK2_9RHOB Unreviewed; 477 AA.
AC A0A1N7HLK2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=SAMN05421666_3363 {ECO:0000313|EMBL:SIS25739.1};
OS Roseovarius nanhaiticus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseovarius.
OX NCBI_TaxID=573024 {ECO:0000313|EMBL:SIS25739.1, ECO:0000313|Proteomes:UP000186019};
RN [1] {ECO:0000313|EMBL:SIS25739.1, ECO:0000313|Proteomes:UP000186019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 29590 {ECO:0000313|EMBL:SIS25739.1,
RC ECO:0000313|Proteomes:UP000186019};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FTNV01000004; SIS25739.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1N7HLK2; -.
DR STRING; 573024.SAMN05216208_3339; -.
DR Proteomes; UP000186019; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:SIS25739.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:SIS25739.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186019};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SIS25739.1}.
FT DOMAIN 8..284
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 322..472
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 477 AA; 51071 MW; 37588C201B3657BF CRC64;
MNDDMITPVL LCGGSGTRLW PLSRKSYPKQ FARLMGDESL FQASARRLSG AGFAAPLVVT
GDPFRFVVTE QLAQIAQAPQ GILIEPEGRN TAPAVLAAAL WLAQRDAGAL MLIAPSDHVI
PDADAFRAAV LAAAPRARGG DLVTFGIAPT RPETGYGYLE LGQGADASAD TPQPLARFVE
KPNAARAEEM LSAGNFLWNA GIFLCTAEAV IAAYTSHAPA MLDAVSAAYD GAANDLGFTR
LAADHWVEAE DISIDYAIME KAANLAVMPF RAGWSDLGGW EAVWLETGPD AEGNVCSDHA
TAISCENSLL RSESADVELV GIGLSDIVAI AMDDAVLVAH KSQTQRVKEA VSALKARGAS
QAVQLPRDYR PWGWFESLAV GGRFQVKRIV VNPGAALSLQ SHQHRSEHWV VVEGTAHVTI
GEEVRLLSEN QSVYIPLGAV HRMENRGKVP MVLIEVQTGS YLGEDDIIRY EDVYARS
//
