ID A0A1N7HNE4_9RHOB Unreviewed; 299 AA.
AC A0A1N7HNE4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000313|EMBL:SIS26377.1};
GN ORFNames=SAMN05421666_3531 {ECO:0000313|EMBL:SIS26377.1};
OS Roseovarius nanhaiticus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseovarius.
OX NCBI_TaxID=573024 {ECO:0000313|EMBL:SIS26377.1, ECO:0000313|Proteomes:UP000186019};
RN [1] {ECO:0000313|EMBL:SIS26377.1, ECO:0000313|Proteomes:UP000186019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 29590 {ECO:0000313|EMBL:SIS26377.1,
RC ECO:0000313|Proteomes:UP000186019};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; FTNV01000007; SIS26377.1; -; Genomic_DNA.
DR RefSeq; WP_076535613.1; NZ_FTNV01000007.1.
DR AlphaFoldDB; A0A1N7HNE4; -.
DR STRING; 573024.SAMN05216208_3598; -.
DR OrthoDB; 9778880at2; -.
DR Proteomes; UP000186019; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF73; 4-HYDROXY-TETRAHYDRODIPICOLINATE SYNTHASE; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000186019}.
FT ACT_SITE 135
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 163
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 47
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 299 AA; 31896 MW; 72253306A858E48F CRC64;
MTLFTGLSAF PLTPTDDNGQ LKPELLQRFL ERIMAAGADS LGLLGSTGGY AYLTPEERKR
TLRTAVECVA GRTPLIVGVG ALTTDVAEDL ARDARQAGAD GLLLAPMSYQ PLTDEEVFRH
FEAVAAAGEL PLCIYNNPGT TKFTFGPDLI ARLAEIPNVT SVKMPLPADG DYAGEMQRLR
AVTPENFSIG YSGDWGAKDA LLAGGACWYS VVAGLLPEPA LALTRAAQAG NVAGVERFDH
AFAPLWALFR EFGSFRVMFA ISEILGFGGI TPPRPILPLD QACRGRVEDA LRPLLQVAA
//
