ID A0A1N7INF8_9CORY Unreviewed; 371 AA.
AC A0A1N7INF8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=S-(Hydroxymethyl)mycothiol dehydrogenase {ECO:0000313|EMBL:SIS38609.1};
GN ORFNames=SAMN05444817_101112 {ECO:0000313|EMBL:SIS38609.1};
OS Corynebacterium appendicis CIP 107643.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1161099 {ECO:0000313|EMBL:SIS38609.1, ECO:0000313|Proteomes:UP000186292};
RN [1] {ECO:0000313|Proteomes:UP000186292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44531 {ECO:0000313|Proteomes:UP000186292};
RA Varghese N., Submissions S.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; FTOF01000001; SIS38609.1; -; Genomic_DNA.
DR RefSeq; WP_076598116.1; NZ_FTOF01000001.1.
DR AlphaFoldDB; A0A1N7INF8; -.
DR STRING; 1161099.SAMN05444817_101112; -.
DR OrthoDB; 334894at2; -.
DR Proteomes; UP000186292; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR017816; MycoS_dep_FDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR NCBIfam; TIGR03451; mycoS_dep_FDH; 1.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF12; ALCOHOL DEHYDROGENASE CLASS-3; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 21..369
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 371 AA; 39125 MW; 4C1464FD39CDC745 CRC64;
MTNNEQQTEQ TVKGVIAREK GADVEIADIV IPAPGPNDVV VKVQATGVCH TDLAYRDGDI
EDAYPFLLGH ETAGVVETVG ADVTHVEPGD FVVLNWRAVC GECRACRKGD TKNCFNTHNA
SKGMTLTDGT ELTPALGIGS FAEKTLVHEM QCTKVNPDED PAAAGLLGCG IMAGLGAAVN
TGEVQRGETV AVFGLGGVGL AAVAGAALAG AVKVIAVDVD KRKCDAAAKF GATDAICSKD
MSEGEVIDRV RELTGGFGPD VTIDAVGIQP TWRQAFYSRD LAGRMVMVGV PNQTDHVDIP
AIDLYARGGS IKPAWYGDCL PERDFPTYVD LHLDGRFPLG EFVSERIGLG DIEGAFTKMK
QGDVLRSVVE F
//
