ID   A0A1N7IT87_9BACI        Unreviewed;       636 AA.
AC   A0A1N7IT87;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Uncharacterized sulfatase {ECO:0000313|EMBL:SIS40226.1};
GN   ORFNames=SAMN05421687_102152 {ECO:0000313|EMBL:SIS40226.1};
OS   Salimicrobium flavidum.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Salimicrobium.
OX   NCBI_TaxID=570947 {ECO:0000313|EMBL:SIS40226.1, ECO:0000313|Proteomes:UP000187608};
RN   [1] {ECO:0000313|EMBL:SIS40226.1, ECO:0000313|Proteomes:UP000187608}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23127 {ECO:0000313|EMBL:SIS40226.1,
RC   ECO:0000313|Proteomes:UP000187608};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the LTA synthase family.
CC       {ECO:0000256|ARBA:ARBA00009983, ECO:0000256|PIRNR:PIRNR005091}.
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DR   EMBL; FTOC01000002; SIS40226.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1N7IT87; -.
DR   STRING; 570947.SAMN05421687_102152; -.
DR   OrthoDB; 5901192at2; -.
DR   Proteomes; UP000187608; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd16015; LTA_synthase; 1.
DR   Gene3D; 3.30.1120.170; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR012160; LtaS-like.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR   PANTHER; PTHR47371:SF1; LIPOTEICHOIC ACID SYNTHASE-LIKE YQGS; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR005091};
KW   Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005091};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        121..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          250..537
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   ACT_SITE        300
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT   BINDING         258
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT   BINDING         300
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT   BINDING         415
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT   BINDING         474
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT   BINDING         475
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ   SEQUENCE   636 AA;  73159 MW;  1F5CA4E24C31C659 CRC64;
     MLTKIKQTLL NNKKKMGTYA GVIALFWLKM YIIQRFVFNL PVENTNEAFI LAFNPLSSIL
     LIFGLGLLIA GRKGLLISYI LGSALLYVNV LFYREYNDFI TLPMIEQVAN LAGMGGSIQE
     ILSVGDIFLF VDVLIAAFLL FYLRVDRFVS FMPKRLEGAA LAIVAIPMFM INLAWAETER
     TDLLERTFDR NMLVQYIGLL NYHAYDITLQ GRTEMKRTFA DSNELVPVIN YVNEQNKEDS
     DKLEGVAEGK NVIILSLEST QTFTVDNTLH GEEITPYFNQ MKEEGIYFNN FYHQVKQGRT
     SDSEFLLDNS MYGLNRGAVF FTHSDNEYEA TPEILSENGY FTANMHANDK TFWNRNGMYD
     SLGYDEYYSK EDYDVTEEKS HGWGYLDEYF FQDSLNKMKD MEEPFYTKMI TLTNHYPFTL
     PEELQTLEAG ETSSTTLNRY FQTMRYQDEA LRQFVEEFKQ SELYDDTVLL VYGDHFGISE
     NHQEAMGEYL GKEVGAFEQF QLQRVPFLIY GKDIPSMKSD TVGGQVDLRP TIMNLLGLEE
     EDDNPIQFGS DLLNEKRDDF VVDRDGNFAN AEYVGIEGVC YDRETGEEVE VEGACEEGFD
     KAQEELNMSD SVIYGDLLRY LDESQLVEEN NETSAE
//