ID   A0A1N7LC32_9FLAO        Unreviewed;      1956 AA.
AC   A0A1N7LC32;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=Alpha-2-macroglobulin family protein {ECO:0000313|EMBL:SIS71374.1};
GN   ORFNames=B0A70_02295 {ECO:0000313|EMBL:PQA97711.1},
GN   SAMN05421796_102195 {ECO:0000313|EMBL:SIS71374.1};
OS   Chryseobacterium piscicola.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC   Chryseobacterium group; Chryseobacterium.
OX   NCBI_TaxID=551459 {ECO:0000313|EMBL:SIS71374.1, ECO:0000313|Proteomes:UP000186246};
RN   [1] {ECO:0000313|EMBL:PQA97711.1, ECO:0000313|Proteomes:UP000238314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21068 {ECO:0000313|EMBL:PQA97711.1,
RC   ECO:0000313|Proteomes:UP000238314};
RA   Stine C., Li C., Tadesse D.;
RT   "Whole genomes of Flavobacteriaceae.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000186246}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21068 {ECO:0000313|Proteomes:UP000186246};
RA   Varghese N., Submissions S.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:SIS71374.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21068 {ECO:0000313|EMBL:SIS71374.1};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MUGO01000002; PQA97711.1; -; Genomic_DNA.
DR   EMBL; FTOJ01000002; SIS71374.1; -; Genomic_DNA.
DR   RefSeq; WP_076450832.1; NZ_MUGO01000002.1.
DR   STRING; 551459.SAMN05421796_102195; -.
DR   OrthoDB; 9767116at2; -.
DR   Proteomes; UP000186246; Unassembled WGS sequence.
DR   Proteomes; UP000238314; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..1956
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5033745369"
FT   DOMAIN          1194..1284
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   1956 AA;  227399 MW;  3FA7E0B8F94BC9C7 CRC64;
     MKTISKCLLV LFVFLGTLSF AQQYYDVQWK KIAEGYKNGE FKSSLPLILE IQKKAIKDNN
     APQLIKSLKA EFGIYKETHD DTKNDYASAF FRKIKETETQ LKNNDLLFFK ILEIEFFEEY
     FNRTRYEIQN RTNTAEGTIF EIETWTKLDY KNYYTQKFAE LLLLDAKLKN VKLEFYKEAL
     GENADYDYYP TLYDWKLKKN IDFLNNQAVF TKDELVANRA DIKSLYENLI SFNKGNPQLY
     FQHQKLMFEN NIKTDDKFLQ KQIDIVNSPE NGEYKILIVK SIAQELQQKS EFKEAIRWIE
     KIKAEYPNSK LLSNLVYLEN TIKQPFVGVF YEEHNIPEKP IHIVAQHKNA DRFEIKIYRV
     NDFKKQLLFL QNINYDEYYK KIDKTLFRND VFEVPNEKDF KPYTTSLEMN GLPKGLYIGE
     YINGKDISKF LFVSTSSRVI YDEKKDYILV ERENGKRKIN TQLQRYYFRD YKNISDTEIL
     IQTDNFAKFP SIKSDYDYNP YLIYDAVSGD FNILNSEYDG ERNYRYHQEL YQVFLDREIY
     RPGQTVHFKV IATAPDYDKC KDFLLVNQEH EVTLFDANHQ KITSQKFKTN DFGSYSGSFN
     IPKDRLNGKF SIYVSGNNSN QKYFSVEEYK RPKFEITFDT IRNEYKYGQT IELKGKVATF
     SGIPLSKTMV NFDIKRENIR NRYFWWYPNE YSNENSVLGK AETNEQGEFT IKIDLKKDEN
     TKGIQVHNYK VNTTVTDLNG ETQSAETNVK VASVSHYLKT NAISEASANE DFKLKVESFN
     YNDVALDKSY KVKLVQLKQP ERIFRNNFKN NIQNLPKMGK EEFLGKFPHD RYDLSDDQKN
     WKVLKTVVDE TKSGKELNFG KLNAGTYRLL IYNIEGKDSI KTEQDFSVWD KNRLGGNQFP
     FLKVIGSKTQ VKRGSTVMLY AYSAIPDAEV NIYVQDGFGA PKLEKRKFSN GIIAFPITIS
     QDKNIEKYNI QFVLAQYNDV QNQYINLNIK NEDPPLKIQL TTFRDKLEPN SKEKWSITIL
     GRQKEKVVAE VLANMYDKSL DKFVANQYSW SKIYRPRNVF KNYNLVIVPT QLYWHKKVDY
     LETKQIVLPQ LKWFDENVFY ELMIKYGLTT DTDGDGIDDM KDACPNVPGL ENYNGCPVPQ
     AMYTQEVSVS EKRSSGMFAD NDADGNLDKG IATAVDTKKQ ELDQVNPRQN LNETAFFYPH
     LKTDAQGNVS FEFTTPKALT KWKLMFLAHT KDDRNAVLEQ DIMTQKKLSV TPNYPRFLRE
     GDELNFQTKI SNLTEKSLEG AVSLQILNAE TNEDISSLFE ITGSIQDFKV QNTGNAVASW
     KIKTPYNKVN SIIIKVVAKA GDFSDGEQIP VSVLSNRMLL TDAIPIFVKE GQTKTFTLES
     LSNHTTGTAE NVRNTLELKT NPIWEIIFAL PDLSQYLNIS SDDWFNTWFA DVVGTEIFKA
     NPRMKAVFDE YKSADLLKSN LEKNQELKQV LLEETPWVLQ SQSETETMNR VARLFEVNQM
     KNSIAKDWNI LLRYQNEDGG FPWLPGYESS YSSSLYILKN LGKMNSWLKE GISEYQPNGQ
     KYMVERLIGY VDSQLERYWK ETEDNPWSNF ALDYLDTRRY WEKEYPISGK GERLKQMIID
     RANKFKVTDL TFYGVHRAAL IYDNYALKDT SKKLINYLKE TSVSSETQGA YWKKNLNDWG
     WYESKAVNHA GAIEALEKIT PNDINFIEES KIWLATQKET NSWGNSRTTA EIIYILMNSG
     KSWTTPEADK ATVIWGGKEL APQTKTTGFL KQTINSDKIN PKLGQVTVSK PGPGIVQGGL
     FWQYYEDINN VKSTETYISI SREFYKKIKT TNGEQLLKIT EKSPLNVGDR ITVKMILNSD
     RPMQYVHLKD MRAAGLEPVD VLSGYQWKNN LGYYQTTKDA STNFYIYYMP KGKYVFEYDL
     VCNAAGNFSS GFATLQNYYA PQMNARTKGD KLEIKN
//