ID A0A1N7M4G1_9FLAO Unreviewed; 797 AA.
AC A0A1N7M4G1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SIS80978.1};
GN ORFNames=SAMN05421789_10791 {ECO:0000313|EMBL:SIS80978.1};
OS Kaistella chaponensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Kaistella.
OX NCBI_TaxID=713588 {ECO:0000313|EMBL:SIS80978.1, ECO:0000313|Proteomes:UP000185839};
RN [1] {ECO:0000313|Proteomes:UP000185839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23145 {ECO:0000313|Proteomes:UP000185839};
RA Varghese N., Submissions S.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; FTOI01000007; SIS80978.1; -; Genomic_DNA.
DR RefSeq; WP_076387116.1; NZ_FTOI01000007.1.
DR AlphaFoldDB; A0A1N7M4G1; -.
DR STRING; 713588.SAMN05421789_10791; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000185839; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..308
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 797 AA; 88679 MW; 0C248EC1EECAC4DD CRC64;
MKRRIKHVTV LGSGIMGSGI AAHFANIGVQ VLLLDIVPFE LTEAEQKKGL TKEDKAVRNR
IATENFVKLQ KSSPALLYSP KFAERITVGN FDDDLEKIKK TDWIIEVVVE RLDIKKSVYE
KIEQHRKPGT LVSSNTSGIP IHFLIEGRSD DFKKYFAGTH FFNPVRYLPL LEIIPTPETD
PEIIKFYMEY GAKFLGKATV EAKDTPAFIA NRIGVFSMMN LLHEVQNLGL NVSDIDKLTG
PVIGRPKSAT FRTADVVGLD TLVMVANGVR DSKAEANDFN DVFALPKYIQ TMIDNKWLGS
KTEQGFYKKV KNAEGKSEIH GLNLDTLEYE LQGKSDFPTL ELTKSIDKPI DRFKVLVSGK
DKAGELYRKS LGALFAYVSH KVPEISDEVY KIDDAMRAGF GWENGPFEIW DAVGVQKGIE
LAKEAGYEVS DWVKTVASFY KVNDEGQTIY FDKNSGNYNS IPGQESFIIL DNIRKNKTLW
SNSGSAIQDL GDGIINFEIR SKMNSLGGEV LDGLNRAIDL AEKDYEGLVI GNQGANFSVG
ANLAMILMMA IDQDWDDLNM AIAYFQKSMM RVRYSSIPVV VAPHGMTLGG GCEMTMHADR
VVAAAETYIG LVETGVGVIP GGGGTKEMAL RVSREFHSDD VKNNRLRDMF MNIAMGKVAT
SAYEAYDMGI LENHKDIVVV NKNRQIKTAK MMALSLAEHG YTQPIEQKVK VLGRDALGMF
LVGTDQMLTG KYISEHDKLI ADKLANVLVG GNLSEPTVVT EQYLLNLERE TFLQLCGERK
TLERIQFMLT KGKPLRN
//
