ID A0A1N7MCG5_9FLAO Unreviewed; 1133 AA.
AC A0A1N7MCG5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=SAMN05421789_10859 {ECO:0000313|EMBL:SIS83661.1};
OS Kaistella chaponensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Kaistella.
OX NCBI_TaxID=713588 {ECO:0000313|EMBL:SIS83661.1, ECO:0000313|Proteomes:UP000185839};
RN [1] {ECO:0000313|Proteomes:UP000185839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23145 {ECO:0000313|Proteomes:UP000185839};
RA Varghese N., Submissions S.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; FTOI01000008; SIS83661.1; -; Genomic_DNA.
DR RefSeq; WP_076387233.1; NZ_FTOI01000008.1.
DR AlphaFoldDB; A0A1N7MCG5; -.
DR STRING; 713588.SAMN05421789_10859; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000185839; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 585..746
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 767..921
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1133 AA; 129338 MW; 03623D78888CAA18 CRC64;
MPLKKITEIF LPQLLHLGFG KELFTQLDQN KHLAVKSFAG SSPSVFAAEL FLIKKKSVLF
LTDDKEDALY ITSELEDLLG KENVLYFPPT HLEPYQIEKT QNANLVLRTE VLSRIHQDKK
PRVMIAPFSS LAEKAMKKED FKAISHTIKT GDQLDFDFTE ELLHQFNFNH TDFVSEPGEF
SVRGGIVDVF SYSNEEPYRI TFFGNEVESI KTFDIETQLS KEKIKEFQLV SNMNFSVLGT
KVSLFDLAPK DLVVITKNAF VGINTIKNFY AKAEEKFGTL STEIKHQKPA ELFVSEEDFV
KDINKFEWID FSIQEVKGST ATIVQLNQKP QPIFHKKFEL LLEDLEEKQN EGFETWISFS
TEKQQERLES ILEDLTAQKS SSEDHDVAAS KVLFKSFRSE LHEGFVDVDH KISVYTDHQI
FDRYQRFKAK NAFAKSEQIT LKDLMQMKVG DYITHIDHGI GKFMGLVKVN NNGKVQECFK
LTYKNGDLLY VSIHSLHKIS KYNGPDGREI VLSKLGSPAW KSLKQKTKAK VKQIAFDLIK
LYAERKTAKG FAFAPDSYLQ NELEASFIYE DTPDQEKATL DVKNDMENDN VMDRLICGDV
GFGKTEIAIR AAFKAATDGK QVAILVPTTI LAFQHYRSFK ERLKDFPVTI SYMNRFRSAK
QKAETLEGLK TGKIDIVIGT HQLVGSSVKF KDLGLLIIDE EHKFGVSVKD KLKTLKSNID
TLTLTATPIP RTLQFSLMAA RDLSVIKTPP PNRQPVETQI VGFNEEMIRD AISYEIQRDG
QVYFINNRIE NLKDIAGLIQ RLVPDAKVIT GHGQMEGKQL ERNVLDFMEG KYDVLVSTTI
IESGVDVPNA NTIFINDAQR FGMADLHQMR GRVGRSNRKA FCFLITPPFD MMSSLAKKRL
EAIEQFSDLG SGFQIAMKDL EIRGAGDLLG GEQSGFINEM GFETYQKIMQ EALEELQNDE
EFEDIFENEE DRKKLFKSTK EVNIDTDLEL MLPDFYVQSI EERLSLYQKL SEIQNKEELR
KLESELVDRF GDLPAEAINL LKSVELKWIA AAIGFDKIVV KNGIFLGYFP SNPQDKFYQS
DKFRNIIAYL NRNPKEATLK EKSSNEGNQL MMRKENVQNV DEVNTVLERI LGN
//
