ID A0A1N7MQD9_9FLAO Unreviewed; 544 AA.
AC A0A1N7MQD9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=B0A70_09580 {ECO:0000313|EMBL:PQA93460.1},
GN SAMN05421796_105133 {ECO:0000313|EMBL:SIS88327.1};
OS Chryseobacterium piscicola.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Chryseobacterium.
OX NCBI_TaxID=551459 {ECO:0000313|EMBL:SIS88327.1, ECO:0000313|Proteomes:UP000186246};
RN [1] {ECO:0000313|EMBL:PQA93460.1, ECO:0000313|Proteomes:UP000238314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21068 {ECO:0000313|EMBL:PQA93460.1,
RC ECO:0000313|Proteomes:UP000238314};
RA Stine C., Li C., Tadesse D.;
RT "Whole genomes of Flavobacteriaceae.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000186246}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21068 {ECO:0000313|Proteomes:UP000186246};
RA Varghese N., Submissions S.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SIS88327.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21068 {ECO:0000313|EMBL:SIS88327.1};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; MUGO01000013; PQA93460.1; -; Genomic_DNA.
DR EMBL; FTOJ01000005; SIS88327.1; -; Genomic_DNA.
DR RefSeq; WP_076451896.1; NZ_MUGO01000013.1.
DR AlphaFoldDB; A0A1N7MQD9; -.
DR STRING; 551459.SAMN05421796_105133; -.
DR REBASE; 263269; M.Cpi21068ORF9580P.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000186246; Unassembled WGS sequence.
DR Proteomes; UP000238314; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..174
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 186..505
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 544 AA; 62042 MW; 39694EC6CC2D9677 CRC64;
MTQKDQYKII GDTLWDIAND LRGAMNPDDF RDYMLSFLFL RYLSFNYEEA AKKELGKEYP
ESPSKEEKLD FRVPPPLALW YDDNEADVKD FEKLMRKKVH YVIEPQYLWS NITELARTQN
GDLLETLQNG FRYIENESFE SAFKGLFSEI NLSSEKLGKT SKDRNDALCK IIGKVAESVA
EFSPDVDTLG NAYEYLIGKF AAGSGKKAGE FYTPQQISTI LSRIVILDSQ NPEAGPKIKL
DKVLDFACGS GSLLLNIRKK IIDKGGKIGK IFGQEKNVTT YNLARMNMLL HGVKDTEFEI
FHGDTLLNQW DILNEMNPSK KMEFDAIVAN PPFSLRWEPN DTLSEDFRFK SHGLAPKSAA
DFAFLLHGFH FLGKEGTMAI ILPHGVLFRG GAEARIREKL LKDNHIDTVI GLPSNLFYST
GIPVCILVLK KCKKHEDVLF INASEQYQPG KRQNSLGENH IDKIVETYQL RPEHIERYAR
RVPIEEIEKN AYNLNISRYV STAEDEVQID LAKVNTDLIE INKLIDSKTK EHNQFLSELG
LNKI
//
