ID A0A1N7MZ20_9GAMM Unreviewed; 370 AA.
AC A0A1N7MZ20;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN ORFNames=SAMN05421760_107137 {ECO:0000313|EMBL:SIS91357.1};
OS Neptunomonas antarctica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Neptunomonas.
OX NCBI_TaxID=619304 {ECO:0000313|EMBL:SIS91357.1, ECO:0000313|Proteomes:UP000185999};
RN [1] {ECO:0000313|Proteomes:UP000185999}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22306 {ECO:0000313|Proteomes:UP000185999};
RA Varghese N., Submissions S.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SUBUNIT: Forms a 24-polypeptide structural core with octahedral
CC symmetry. {ECO:0000256|ARBA:ARBA00011484}.
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR EMBL; FTOE01000007; SIS91357.1; -; Genomic_DNA.
DR RefSeq; WP_054340812.1; NZ_LJSI01000027.1.
DR AlphaFoldDB; A0A1N7MZ20; -.
DR STRING; 619304.SAMN05421760_107137; -.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000185999; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF12; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Pyruvate {ECO:0000313|EMBL:SIS91357.1};
KW Transferase {ECO:0000256|RuleBase:RU003423, ECO:0000313|EMBL:SIS91357.1}.
FT DOMAIN 1..76
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 117..154
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 370 AA; 39771 MW; 23656E2A5354831E CRC64;
MKYFKLPDLG EGLPEADILE WHIKEGDLVK EDQLLVSVET AKAVIEVPSP QTGVIAHLFG
AEGDTVHTGE PLVEFITDDE DDSGTVVGTL ARADNTSQED NFIIGASPSS LAHRQQRATP
AVRALAKRLD IDIDTIKATG HQGGVSVSDI EQAARLNQQF GAPERLKGVR KHMAKNMSQA
HADVAAVSIF DDANISHWVA KTDITMQLIL AIAAACKQEP IMNSWFDGQQ LTIRQHQHID
LGVAVDTDKG LFVPVLRDIA GRSESALREG LNKLRTDVAA RTIPAKELQG ATITLTNFGT
MAGRYATPIV VPPQIGIIGA GVIRDEAVVQ TGTIVIGRIL PISLTFDHRV ATGGEAARFL
KVVIATLEDN
//
