ID A0A1N7NU92_9FLAO Unreviewed; 505 AA.
AC A0A1N7NU92;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN ORFNames=SAMN05421789_11733 {ECO:0000313|EMBL:SIT01789.1};
OS Kaistella chaponensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Kaistella.
OX NCBI_TaxID=713588 {ECO:0000313|EMBL:SIT01789.1, ECO:0000313|Proteomes:UP000185839};
RN [1] {ECO:0000313|Proteomes:UP000185839}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23145 {ECO:0000313|Proteomes:UP000185839};
RA Varghese N., Submissions S.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|RuleBase:RU000417};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; FTOI01000017; SIT01789.1; -; Genomic_DNA.
DR RefSeq; WP_076388434.1; NZ_FTOI01000017.1.
DR AlphaFoldDB; A0A1N7NU92; -.
DR STRING; 713588.SAMN05421789_11733; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000185839; Unassembled WGS sequence.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 505 AA; 58047 MW; EAC2F0DA2783F853 CRC64;
MVFKNIDQIT DKKDKSKLIE KIQLHIRIVQ CLSEIHKIVF DKVSSDVKLN TISKIKDIGI
ISNEDDIIVL QKLINPLFID FIKSVNFSLL YPKLIGSHLD KLNNKIRLEY QKKEARTSKP
TVVDFFCGAG GLSLGFVKAG YKVIFANDHE DVCIDTYSYN HPEVKNTSIV NGDIKDIVNN
LEDFINKDAD IVVGGPPCQG FSSANQQRII DDPRNELYKY FIKAVEKLSP KFVVMENVRG
MLPYANQIKE DYQNIKSFKD NKNYTYEIDC RVLTSNDYGV AQKRHRLIFI AIRKDIGLQF
NVSPSDILNN IVSTKDNNEQ FHLSDALNFI KELEANRKKN TNELDSEVSG KKVEVNSYTG
TENSYLLSIN ENRTMPIIFN HKARFVSDLN FDIYRLLNQG DDATNEKIVH LMPYAHRNNV
FKDKYYKLIA DRPSRTITAH LRMDCHSHIH PFQVRSITPR EAARIQSFPD DYVFLGAYLK
TYMQIGNAVP PLMAKVIAEN IIKYL
//
