ID A0A1N7PQ92_9RHOB Unreviewed; 892 AA.
AC A0A1N7PQ92;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05421774_10627 {ECO:0000313|EMBL:SIT12599.1};
OS Gemmobacter megaterium.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Gemmobacter.
OX NCBI_TaxID=1086013 {ECO:0000313|EMBL:SIT12599.1, ECO:0000313|Proteomes:UP000186141};
RN [1] {ECO:0000313|EMBL:SIT12599.1, ECO:0000313|Proteomes:UP000186141}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26375 {ECO:0000313|EMBL:SIT12599.1,
RC ECO:0000313|Proteomes:UP000186141};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FTOT01000006; SIT12599.1; -; Genomic_DNA.
DR RefSeq; WP_076532433.1; NZ_FTOT01000006.1.
DR AlphaFoldDB; A0A1N7PQ92; -.
DR STRING; 1086013.SAMN05421774_10627; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000186141; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000186141}.
FT DOMAIN 703..719
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 629..636
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 892 AA; 96746 MW; F751F15ECC921B04 CRC64;
MTDTVTPMMA QYLEIKGQHA DAILFYRMGD FYEMFFDDAV QASAALDIAL TKRGQHLGAD
IPMCGVPVHA AEGYLLALIR KGFRVAIAEQ MEDPAEAKKR GSKSVVRRDV VRLVTPGTLT
EDSLLEARRH NYLAAFSEVR DAGALAWVDI STGEMRVMPC PAVRLGPELA RLAPREVLLS
ETQAALCPVV TESGAVDTLR PRSGFDSTGA ERRLCGLWSV STLDGFGAFD RAELSAMGAL
VDYLDLTQRG RLPLVRPPVR ELAGGLMQID AATRRSLEIT HGSNGGRDGS LLATVDRTVT
AAGARLLERR LSGPSRDLNL IRQRLIAVRS LAENARLRDQ LRTLLKAVPD MERAQSRLAL
DRGGPRDLAA IRDGLYHAVE IADILAGWQD APVLLGEAAR SLTGHDALVS LLRSAVVSDP
PLLLRDGGFV AKGFDSELDE TRALRDEGRG VIARMQADYA VETGIQTLKI KHNNVLGYFI
EVTDRHAERM MTPPLSERYI HRQTTANQVR FTTVALSALE TRILNAASHA LQLERGHFQS
LQSTVLASSG AIAQTSRALA EIDVACALAD LAIAEHWCEP IVDDSHAFEI SGGRHPVVER
ALRRAGEPFV ANDCLLSTGE SPAIWLLTGP NMAGKSTFLR QNALIAVLAQ AGSFVPADSV
RIGLVSQLFS RVGASDDLAR GRSTFMVEMV ETAGILNQAD ARALVILDEI GRGTATYDGL
SIAWAVLEHL HDTNRCRALF ATHYHEMTTL AGRLKAVENA TVSVKEWQGE VIFLHEVRKG
AADRSYGVQV ARLAGLPSSV VDRARVVLEA LEKGEREGGR TRTMALIDDL PLFSAASAAA
PRTAAAPPSQ VEDRLHKINV DDLSPRQALE LLYELRGLMA KPDQTPAPPS SR
//
