ID   A0A1N7PV15_9RHOB        Unreviewed;       506 AA.
AC   A0A1N7PV15;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase {ECO:0000313|EMBL:SIT14402.1};
GN   ORFNames=SAMN05421774_106158 {ECO:0000313|EMBL:SIT14402.1};
OS   Gemmobacter megaterium.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Gemmobacter.
OX   NCBI_TaxID=1086013 {ECO:0000313|EMBL:SIT14402.1, ECO:0000313|Proteomes:UP000186141};
RN   [1] {ECO:0000313|EMBL:SIT14402.1, ECO:0000313|Proteomes:UP000186141}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 26375 {ECO:0000313|EMBL:SIT14402.1,
RC   ECO:0000313|Proteomes:UP000186141};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; FTOT01000006; SIT14402.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1N7PV15; -.
DR   STRING; 1086013.SAMN05421774_106158; -.
DR   Proteomes; UP000186141; Unassembled WGS sequence.
DR   GO; GO:0018480; F:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity; IEA:InterPro.
DR   GO; GO:1901023; P:4-hydroxyphenylacetate catabolic process; IEA:InterPro.
DR   CDD; cd07093; ALDH_F8_HMSADH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR011985; DH_HpaE.
DR   NCBIfam; TIGR02299; HpaE; 1.
DR   PANTHER; PTHR43720; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43720:SF2; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186141}.
FT   DOMAIN          43..492
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        269
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   506 AA;  54120 MW;  90F97BC3EAD0433B CRC64;
     MPAQMNDLAS NLSRAGAHLQ RFKDGGVLNH IGGHAVEGSL GWFDTISPVD LTTLAKVAHG
     GRPDIDQAAQ AAQAAFADWA RMDGGKRRKL LHRIADAIEK RAEEIAFLEC LDTGQALRFM
     SKAALRGAEN FRFFADKAPE ARDGRSIFGP GQMNVTSRAP IGPVGIITPW NTPFMLSTWK
     IAPALAAGCT VVHKPAEFSP LTARLLIEIA EEAGLPPGVW NLVNGMGEDA GRALTEHPLI
     KAIGFVGESR TGSRIMAQGA ATLKRVHFEL GGKNPVIVFA DADLDRAADA AVFMIYSLNG
     ERCTSSSRLL VEESVYDAFA AKVAEKAARI PIGHPLDPRT VIGPLIHPVH EAKVLSYFEK
     ARAEGATIAT GGEKLDGPGC YVRPTLFTNA RNDMAIAQEE IFGPVLTAIP FADEAEALAL
     ANDVQYGLAG YLWTGDLTRA LRMTEAMQAG MIWVNSENVR HLPTPFGGVK SSGIGRDGGD
     WSFDFYMETK NVAFATAAHG IPKLGG
//