ID A0A1N7SDJ4_9BURK Unreviewed; 324 AA.
AC A0A1N7SDJ4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=citrate synthase (unknown stereospecificity) {ECO:0000256|ARBA:ARBA00012972};
DE EC=2.3.3.16 {ECO:0000256|ARBA:ARBA00012972};
GN Name=prpC {ECO:0000313|EMBL:SIT45446.1};
GN ORFNames=BN2475_550049 {ECO:0000313|EMBL:SIT45446.1};
OS Paraburkholderia ribeironis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=1247936 {ECO:0000313|EMBL:SIT45446.1, ECO:0000313|Proteomes:UP000187012};
RN [1] {ECO:0000313|EMBL:SIT45446.1, ECO:0000313|Proteomes:UP000187012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=STM7296 {ECO:0000313|EMBL:SIT45446.1,
RC ECO:0000313|Proteomes:UP000187012};
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|RuleBase:RU003406}.
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DR EMBL; CYGX02000055; SIT45446.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1N7SDJ4; -.
DR STRING; 1247936.BN2475_550049; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000187012; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR011278; 2-MeCitrate/Citrate_synth_II.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR NCBIfam; TIGR01800; cit_synth_II; 1.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF25; CITRATE SYNTHASE-RELATED PROTEIN DDB_G0287281; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:SIT45446.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000187012};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003406}.
FT ACT_SITE 209
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 260
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 324 AA; 35565 MW; 9360980A96C6AF3A CRC64;
MHGKLPTQAE LTAYKTKLKG LRGLPANVKA ALEWIPAAAH PMDVMRTGVS VLGTVLPEKD
DHNLAGARGI ADKLMASLGS MLLYWYHYAH NGRRIEVETD DDSIGGHFLH LLHGAAPSKS
WVDAMHVSLN LYAEHEFNAS TFTGRVIAGT GSDIYSAITG AIGALRGPKH GGANEAAFEI
QSRYQSPDEA EADIRRRVEN KEVVIGFGHP VYTISDPRNK VIKEVAHKLS KEAGNTKLFS
IAGRLESVMW DAKKMFPNLD WFSAVSYHMM GVPTAMFTPL FVISRTAGWS AHIIEQRIDN
KIIRPSANYT GPDDLPFVPL AKRV
//
