ID   A0A1N7SWS9_9BURK        Unreviewed;       554 AA.
AC   A0A1N7SWS9;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Uncharacterized Na(+)/H(+) exchanger YjcE {ECO:0000313|EMBL:SIT51820.1};
GN   Name=yjcE {ECO:0000313|EMBL:SIT51820.1};
GN   ORFNames=BN2476_1450001 {ECO:0000313|EMBL:SIT51820.1};
OS   Paraburkholderia piptadeniae.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=1701573 {ECO:0000313|EMBL:SIT51820.1, ECO:0000313|Proteomes:UP000195569};
RN   [1] {ECO:0000313|EMBL:SIT51820.1, ECO:0000313|Proteomes:UP000195569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=STM 7183 {ECO:0000313|EMBL:SIT51820.1,
RC   ECO:0000313|Proteomes:UP000195569};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC       external protons. {ECO:0000256|RuleBase:RU366002}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU366002}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU366002}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
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DR   EMBL; CYGY02000145; SIT51820.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1N7SWS9; -.
DR   OrthoDB; 9809206at2; -.
DR   Proteomes; UP000195569; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   NCBIfam; TIGR00831; a_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU366002};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU366002};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU366002};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM        56..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        85..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        157..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        182..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        218..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        242..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        277..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        316..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        361..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   DOMAIN          8..420
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   554 AA;  59498 MW;  D31B016FE16C9838 CRC64;
     MEIVFTVLIL LLAVAVSGVV VRLLRGLLPL PLVQIAIGAL LAWPKFGLYV TFDPQLFLLL
     FIPPLLFADG WRTPKREFFM RRRSILLLAF GLVFMTVLVV GYFVHALVPT VSLPIAFALA
     AVLSPTDAVA LAGIAGKNRI PPHLMHILEG EALMNDASGL VALKFAIAAA LTGMFSLREA
     SITFVIIATG GLAMGAAVSW LFSVVIRRLR SVTGEGDPAP GVVLTLLIPF AAYLFAEHFH
     CSGILAAVAA GMMMNYATIT SAGTVSARVK ANSTWTMVEF VFNGMVFILL GLQFPHIIGR
     ALLDAHETGN GDVWRLIGYV AAVTLALYTM RFVWVWLLRW LASLGAARQG VINAVPGLRT
     VTIMTVAGVR GALTLAGVLS IPVALSSGEA LPGRDLVIFI ASGVILTSLL VAVFALPQLL
     HGAHHAHDAH AVEEQHARKV AAQAAIRAID DLHPTVTGDI GEPATAFDAD VAARVMDLYR
     RRLATLTDDR HSTDEVRRAE ALEIQISLAA MRAERAALLA LRNTHEINDE TLSKLMREVD
     FSETALTTRE QAGT
//