ID A0A1N7SYP3_CAEEL Unreviewed; 5059 AA.
AC A0A1N7SYP3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Microtubule-actin cross-linking factor 1 {ECO:0000313|EMBL:SIT60411.1};
GN Name=vab-10 {ECO:0000313|EMBL:SIT60411.1,
GN ECO:0000313|WormBase:ZK1151.1l};
GN ORFNames=CELE_ZK1151.1 {ECO:0000313|EMBL:SIT60411.1}, ZK1151.1
GN {ECO:0000313|WormBase:ZK1151.1l};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:SIT60411.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:SIT60411.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:SIT60411.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284601; SIT60411.1; -; Genomic_DNA.
DR RefSeq; NP_001335521.1; NM_001348623.1.
DR SMR; A0A1N7SYP3; -.
DR STRING; 6239.ZK1151.1l.1; -.
DR EnsemblMetazoa; ZK1151.1l.1; ZK1151.1l.1; WBGene00006876.
DR GeneID; 173058; -.
DR AGR; WB:WBGene00006876; -.
DR WormBase; ZK1151.1l; CE51904; WBGene00006876; vab-10.
DR InParanoid; A0A1N7SYP3; -.
DR OrthoDB; 5489926at2759; -.
DR Reactome; R-CEL-351906; Apoptotic cleavage of cell adhesion proteins.
DR Reactome; R-CEL-446107; Type I hemidesmosome assembly.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-6809371; Formation of the cornified envelope.
DR Reactome; R-CEL-9013420; RHOU GTPase cycle.
DR Reactome; R-CEL-9013424; RHOV GTPase cycle.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00006876; Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; A0A1N7SYP3; baseline and differential.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0030056; C:hemidesmosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0042060; P:wound healing; IBA:GO_Central.
DR CDD; cd21189; CH_PLEC-like_rpt2; 1.
DR CDD; cd00176; SPEC; 9.
DR Gene3D; 1.20.58.60; -; 23.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 6.
DR Pfam; PF21020; Spectrin_4; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00150; SPEC; 26.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 23.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51460; GAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:A0A1N7SYP3,
KW ECO:0007829|PeptideAtlas:A0A1N7SYP3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 306..413
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 944..1001
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 4833..4905
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 41..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4933..5059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1263..1317
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1965..1992
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2313..2382
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2428..2514
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2569..2596
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2759..2793
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2870..2897
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3704..3752
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4624..4658
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 41..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5000..5025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5059 AA; 571898 MW; BD2E9200A89AE07F CRC64;
MDLLLDYFYF CAREVLCHTF GITCATGAGS EIALVARDPT TYYRPSSSNS DPTYRETGTP
ISWSEGGGGL SSTSSSSCPS ASSQFPLILR SSPSPPQPPQ QQHAQHREYS SFSFSSSSFT
TPSSSSSYSS SSSSSSSNSH ACDHCDSYVW HATSCLATTA LLLFGLATTL TMLKVVRSYS
KKAERKSESS RASAQGGSQQ AISGGGGAGA GGGGNSSYYE EYSSRNGAAG GNGHVGNGGG
QIIHHAHNQH LSNAQQAHGG FSESSSYETR EHFERKVQRV KKTRGERERS RSGKRDDVSL
HGSDATSARD ALLQWARRVT AGYPRVNVNN FSSSWRDGLA FNAILHRYRS SAIDWNKISS
DSVSNTERLN NAFAAADREF GVERLLDAED VDTNNPDEKS IITYVSSLYN ALPHEPEMSR
LQKVQEEYIE EAYEWREWVV RAIQLVDDRH LQGTASELIY ELQRFREDDL PPREEQKRRL
TLVYEHLEKV MRSTELFAIP HELSAPELQR VWNELQNSID RRFDVLERHR IQEGNSNDLL
SRLARGIGIT NEKLDLILKR IEDVEARVDT SPPAAVERTV SEIVDDLNAL ESPIARFFED
VEELKSMQHP EANDFYKQVY GLHQRRTTYL DRLTNQILVR LGVRTDSLHK ENQQRLENMR
KTSFSRVEEC IEWVRVRMEK LTTMEFLEDL ETLEHVFEQH KFDNRDIQDF RQNVDECIAR
QAEVSAEDTY EYCELLRVLE SEYQQLRDLS AGRMLDLDSL IAFVRAAQLE LIWVSERESI
EVTRNWSDIK QLDLPMLTNY YKQLLHEMEL REKQYNDVHN QGAALLNQGH PAIRVIEVYL
RQMQSQWDWL LALSKCLEEH LRDALNLKSF MEEASDAEAW IQEQSVRLEN NYNRTDFSLE
EGERFLRELD EIKEILNKYH QVLMALTERC ASISPLWQRG ERIPHPIKVT ALCDYSDENV
TIKAGDDVYL LDNSDLIKWT IRDISGAEGQ VPSVVFRIPP TDARLTALLN RLLQQFEKLK
KLWDKKHRMV RFNMVLNTMR TIQGWDLDTF NSIDPDQRDA IMKALNDDAN KLLSELDPND
PLALRLREEL RRTNEHFWNL LNASQKPPEP DWASQYDQKM AELLKKLEEA WRELNDAVGK
PISRSPEDLE RVIHAHKRFE DALQALDSDV ANVKELFRQL PNPTPTQRVN HDRLNGLWDD
LWDLSRMYVE RIKVLESVLN GMVEVADIVR QHEITLNSFD DLPAALDKLR GHHSQLLEIN
MVLKQQQTVI DQLNRNVALL RQHVSRTRIN EGHHPDVDAI EDEVQKLNVR WENVNSQIAS
RLLAVESALQ IQMVYRSEYE TEMSWLDTVE ETINRLRKPE ELRPEQYQQQ LDMLIAEYTN
LQEHTQAIEH VNKEGGRFIH EAKIFDAKLG QYSDGIVGIH GPGIKSEFRR TKPQPKNGSQ
IVTEELELLN RRFAQLSSLI LERRNTMQVL IQNWKRQKQE NVTQVVSFRE AEVSGMMTDL
TRFRQEIFTT HLTFNSNPES IDAATKNVQN VKQSLDSWRD RIKERLDEID RLCTEEGDSL
TPEQYSALRE MRRQLADEYD TVLRTVEGIH TRLNILSALL IEFSSVTSSM QSWMTDRTRL
AGDIRHKSGD PMRIDEARFE AKSLMDEVIR EESRLKTIGA SVLKIEQEIS AMRDDVRASG
STDDVGISVD EVYETRRRVE DDYMQLLRQC QDLISFQNRL HAMNDEHSEQ ARRADEWLQM
LQNDVEDVDQ DPRFQRDEDR IQRIEELNRM AAGGSSQLDD AEQASRRLLT ALEGTNVAND
VRARHEELAN LRRGKHQKVI DRLSQNMMEA ASRKAEAEGV KQAVENLRQW SEQTAQRTRQ
PVQLPLTELD LHEARKDEQV LHGEIENRLA LIEELEKKAA DVGDHASLAE LQECKMKLKR
SNSDLKGLRD NIFDAINGLQ TVNSEGETLS RAVDSAGAKI RSARLPEAQS EVEALQDQAD
NLERITNNLC NIPNVTRTEP VIQKSKDLRK RVDSCAQELD ARMGKLAELE SLDAEFDGAK
NKLSSFIGAF DDELKGLEKV SIDKEKLAEQ RRQTQDLVDK HSEGNAILDD VEAIAQKVTA
EDPSKTGSAQ KSVGELGARL QRQASELKAR GDKINKLDSK ATSFAESEAA VLGYIEKQKD
QLSTGFPVPA TKEGVKSQLL DLERMNKTGK EEQRRVDDAR HSARELAREA SVEKEVQDMN
QREKKLLDEW EDLADQFDAV RSRANKAEQV LNECAQMEKY IGAKKNMLEG IGAPSTEPGV
AKANRAQIQS MKAETEGEKS ALEHVNSLAN ELIADGGANV EELMKKMDRL NRKWHSLESG
LDENAGRVEE AAKLGQELKD IQKELRKELG ELESNVEKAS AMSSNDIGDQ LATLDSLKSR
FGGVDKALEK LKGILEATEE LEVDATNRAE IQEQLETTQK KADELERKIE NVKKAALNAQ
NEGLELEKKL DELIGTVNSA ENELELAAPI AAESLKLADE LKRAEELFQK LIENEGDVSL
IRAKVAEELK KKPDAELKKK LELLYQKWPK ALGAARDRKD LVSKAGDLVK QFGDQVQALE
QRLQGDQAEL DELLASDKAH DPEVCDALKL VELTMARRLA DVDALNAVMN RIESSAPGPD
ANRLRRRADT LSDDAKGMAK KARTAADLAQ RKQGLAKKFE RLCDEVSQFT ENQKAEIQDA
IEKDLLNAER VQSKLNKIDD FWSSNSRELK NVGDEIKIDA TPEDAQAVDT KLAELQAGID
GLLATLQEQN VHLEEKREQA NRVQSESQKA AGKINSLVAE IADLDPIGRS RDELQKQKKE
VVELAGDLGS AQTKMLELGA EWEAALGAGI VAQPVFEMNR AATDELNKLA ARAGKRLAQR
EKKITETEDE IDKLHADADQ IVGALEAIAK DEALQGAPSQ LLDPKQVSEK VRQLKESLKP
VGEKMDAFNT DCKLLIKTAG PESDTKELDS LLKKVGDAYS DVVGKVSDKE MSVDAAVQQQ
GKVEDAYRAL LNWLEETEEM MENRKKPSAD AKVAKAQLHD YEVLMKHVED KKPSVDGFKA
MIEKIVAEAS SDEEKKALGN KNAQIEDRYK DLLNSAVDRQ RKLLDAVDLA ERLQEVTIPL
DSWLQSADKR LQALAKVPIT VEKAEEMIGE QEALQDELEH KSDDLKDVLE IAPMLASLVS
VEDANSISGQ VNQLEARARA LDAGITNMRP LLESFLQQIQ DFTLDAEDMT QFVGETEVKL
GELDELPIEP DDLVEQTNIL AEIAVSIADR DEMMANIFEV GKQLAIQGEP EEALIAQKKL
DDLKFRYADL MTSADEKIAL LAKAIPLSEG FHEGFDTVMQ VLEDMDRDLQ TIDEEDPETQ
AELIFLLEED ISQKMRPSVD ELTALSNQLQ VLCSADKADE LQTNTIAMNK LVNSVADRVA
RRAERIEMAS KQSRAVLDDL QYLIEWFSAA RERILEGAPP SLDLEVLKSQ LKHQRITNEE
ASANKVQFRN VAGEAKKVAR QLGMEGNEAN EKISDTVDEG KELVEEVMAL CADRTETLER
ALALMEQLTS QFDELNKWLD QMDAELQASP SVTTATPAAE LREMHDHNEE LARMVAAYRP
IIEGFKSDVG SLHEVLAEDQ APLLESVAGE LVQGYEEVRE AVRARGHAID NMMGATIGFG
ERLETLVANL QGAADRLREN EGISADPSVL ESRLAENRSI VESLRDKQNA YDALKQTASE
LLASAPEGDA AAGDVENKLN RLEKLWKEIE REAVDRGVLL EDVLDKAKHF WSELDSCQKA
VDDLRNRLEL VEPATGHPEQ LADQQEIMAQ VASEMERARP RIEALSIAGK QLADYVPDDE
KAVIENQVAN VRGGFSTITG LFAEKKRDLI AAMEEAMTFH GDLQELLKWL DMAEQKLLKM
SPVEHAKHMT EIEQLLKELH TFKDEVHERG VAKEQVVATA LQLAADAPPH LAATVRQPVA
DLNTRWSRLN AALAEREHKL ENLMLQMGKL ASTIAQLTAW MDKTRATLKD IAPPKNAVNL
RDIEIAQCKL VVLSNDIHAH QDSVNAVNRA AQKYIQTSGA LDAETSDSLK SMNLKWEDIQ
KVLESLAFDM EVAKKEAENV GGEVEKWQRW LEETESALLS TKPTGGLPET AEFQLDEFKA
LKLDVEHNAS PLEAHLHATE QHLKEEPQDA DTWLSKTHGA MKTKWNKVKE LLVDREKKLQ
VAYEQAVALE SALNDMEDWI IAAERKLTDQ PSISRLPDVI EKQLAEHESW MEEVAGRKMA
MTKHQASGVH MQYYCEKKDA IPIKNRLVSL KHRVEKISGR TAERAKQLAV TRDEVATWQD
GLHDLEHFIS DVLVKIAPEP NTTSSLEKLK AKLEEVKEAQ RDVTAKQTLF DVTRKRGIGL
AERATRSEYK QISMTNEKMS KKWAEMLKKL RDRLREAEQA VLEGGAFEES MNDLESWVDD
ELERYQKAEH EPVFADIDGV RALVDEESRR SAERKTKENG VKTVVKKADA LMASGVDEKD
SIAQAKERLV EKWNQVEEAA RHRGNSIKEA EQAAEEFDAK THALLDWLAV EEQKLKASGL
DEVEGVKQEM DEAKGRYQEC LKKGEEILSK CQPAAEPILR NWMRVVEARW KEVSEKVDER
EFTLLEQEQK AKEQNEQIEK LAKFAAQKRE ELNRMIEQPP AQDLDTMEQN ICDFANLDSE
LREQQPEVDA ACKSAKKGAR NPAAEMLSTE WKKLWLDAMG LQSSLDNQKA LLEEMKRLEG
WKWEDWKERY VEWNDHAKAR VNDLFRRIDR LHTGNVPRQV FIDGIIGSKF PTSRLEMAKV
ADRFDKGDGM INAKEFINAL RFDASNRNAK PQTDTEKITH EIELQKKTCS CCTPYQIEKI
SENHYRFGDT HIKRMVRILR STVMVRVGGG WESLDEFLHK HDPCRAKGRL NINMFPEARP
IHALDSMRSF TKNRHGKQLP TTGTPGPIMK IREKTDRSVP MSGGLGGTAG YTVTTDSHRH
TDARPSRIPR APSDMSAGRL SRVGSVSNSK NSIVDSSTPS RPESRASSDA GDRQTRIPSL
RARKGQRYIP QGPSSSSSK
//
