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Database: UniProt
Entry: A0A1N7SZF8_CAEEL
LinkDB: A0A1N7SZF8_CAEEL
Original site: A0A1N7SZF8_CAEEL 
ID   A0A1N7SZF8_CAEEL        Unreviewed;      1034 AA.
AC   A0A1N7SZF8;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   18-SEP-2019, entry version 20.
DE   SubName: Full=Ligand-Gated ion Channel {ECO:0000313|EMBL:SIT60427.1};
GN   Name=lgc-45 {ECO:0000313|EMBL:SIT60427.1,
GN   ECO:0000313|WormBase:W10G11.16a};
GN   ORFNames=CELE_W10G11.16 {ECO:0000313|EMBL:SIT60427.1}, W10G11.16
GN   {ECO:0000313|WormBase:W10G11.16a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:SIT60427.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:SIT60427.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:SIT60427.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; BX284602; SIT60427.1; -; Genomic_DNA.
DR   RefSeq; NP_001335537.1; NM_001348629.1.
DR   EnsemblMetazoa; W10G11.16a.1; W10G11.16a.1; WBGene00021146.
DR   GeneID; 189345; -.
DR   CTD; 189345; -.
DR   WormBase; W10G11.16a; CE51895; WBGene00021146; lgc-45.
DR   OrthoDB; 998135at2759; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   ExpressionAtlas; A0A1N7SZF8; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A1N7SZF8,
KW   ECO:0000213|PeptideAtlas:A0A1N7SZF8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25   1034       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012523698.
FT   TRANSMEM    937    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1001   1021       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      671    850       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      879    980       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      295    370       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      384    410       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      474    500       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      182    205       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    302    336       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    341    355       Basic. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    392    410       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    482    500       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   1034 AA;  117839 MW;  0A01F9C97EA2A8C7 CRC64;
     MPRHNHFILQ CLLLLCLLFT CLDSRRRGQS GRTFEDSKAE ERHFDFKAAP GEEAAEEVEE
     KPKIVLASKG DSGSTVATTV APKVEVEEEA TTQSTEDLVK KLLEGVFDLE NLTKIVEEEH
     AEALDEATNR TVLWIDTSYK AMDYNLSTDD FEECATWQKY WNLTAELEKN KDRNLSSSGN
     DTEDVVSEID ELKETEENLK QTELVNTKNR LKALGLNPEL LVAYKAVGLV YREICGNHGR
     TLWYRTREDA SLIGVDSFSP ICEPFKEQLN PDESTLSQLA LKLNILIQNV TEGFEPALRR
     GGGGNTTSTE DGEIQNSTML TSKEPEAVTS DDSEQLTTSH PAHHHHHHHH HQHHQTPPAP
     STETPETPTT AQQADYEIND DEYDNRVFSS GLPPEEPTTT TEPTTTTTES ISEVEVYDDD
     VWDYRDMEKR FKVRHQVVFD GNEIGEDELD GSFPSIHQAS NRKRRRHVVL KTKIRRRRRR
     KRAAGSDEED EKKSSETVID VHQDSGENDE DWLNVRQVIK TTDGETTVAI IEERSHLLDG
     NSTDVRAWIE IDASDLINPT LLISSPEAVA ALGLEVEATA FQRFENVGLY LPGICSEYVP
     KAIDEFNSSS FEGIEIEGPI GVNITALELA GVNLTSLADK LRNDTEVDEI LSRTNGSTKN
     LGGSFILPVL NKNQYDPFSA PIVFQGSAVV VRFGIYIESM SNFQTSTMDY DMDIYLMMSW
     RDARLVNPYD KPILVKEEDI LEKIWRPDPF FANAKEAEFH EVTFLNFLMR IFPDGLVLYE
     TRVKIKPSCN LILCKYPHDK QTCDLLIKSF AYPVETVRFE WFTRRKDAID KNPDVKLPEL
     YIDRYETTTC PNERKSGAFS CLRAVFRLKR DVGFHIAQTY IPTSLALMFS WVGVWLPEEF
     MEGRIGVAIT VLLTLSTESA GAREHLPSVS YLKAIDLWFG FITGFVFFTL LQTLFVIGFD
     KRANQLKKWA GRKTADITEE IREALLQKAT RYHKTGRYLD NFCRVFYPLS FILFLLMYYF
     VFTEGRQDDC MNRR
//
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