ID A0A1P6BHC0_BRUMA Unreviewed; 401 AA.
AC A0A1P6BHC0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Protein artemis {ECO:0000256|ARBA:ARBA00039759};
DE AltName: Full=DNA cross-link repair 1C protein {ECO:0000256|ARBA:ARBA00042677};
GN Name=Bm10789 {ECO:0000313|EMBL:CDP99657.1,
GN ECO:0000313|WBParaSite:Bm10789.1};
GN ORFNames=BM_Bm10789 {ECO:0000313|EMBL:CDP99657.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP99657.1};
RN [1] {ECO:0000313|EMBL:CDP99657.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP99657.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP99657.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP99657.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm10789.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
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DR EMBL; LN857010; CDP99657.1; -; Genomic_DNA.
DR STRING; 6279.A0A1P6BHC0; -.
DR EnsemblMetazoa; Bm10789.1; Bm10789.1; WBGene00231050.
DR WBParaSite; Bm10789.1; Bm10789.1; WBGene00231050.
DR OrthoDB; 23465at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR PANTHER; PTHR23240:SF38; PROTEIN ARTEMIS; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 290..366
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
SQ SEQUENCE 401 AA; 46514 MW; 78A0C5648D158886 CRC64;
MNAFCGRFNE CNWISVDQFH SNNLKSSAFF LSHCHSDHMQ GLDGDQFYEL IKGKFAVLYC
HKISKIFLGS ELHHARLLEH IVPKNYNEKF TVTAICDNEE RESLLPSSSA DVTFLDAQHI
PGSIMILFEF HGGFRLLYTG DYRLSKDDWI ACDMLKDPYA SSGFKRLDAL YFDSTFCRKG
AENIPSLKQS CALCVKMVKG WLEKDSDNKV LIWCGRFGHE LLLKAIWDEL HIKCHVTMMK
YRIYSKIDFL AECITPIARN TRVHACTAKP TVTEEVFFEN KQNVVAKKKN DVSFKQTMST
CWLCRPDHNN VRVIKPSAIW FLRRNKKNVL GYENNRFCRL FYSGHCSVSE MEDAFSLLRP
VRAYPNSTDK RSKDFAKKLS MYFRFAQTKE EEGRLMNVSS M
//
