ID A0A1P6BTQ0_BRUMA Unreviewed; 803 AA.
AC A0A1P6BTQ0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 13-SEP-2023, entry version 29.
DE RecName: Full=Hepatocyte growth factor-regulated tyrosine kinase substrate {ECO:0000256|ARBA:ARBA00015450};
GN Name=Bma-hgrs-1 {ECO:0000313|EMBL:CDQ04559.1,
GN ECO:0000313|WBParaSite:Bm2052b.1};
GN ORFNames=BM_Bm2052 {ECO:0000313|EMBL:CDQ04559.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ04559.1};
RN [1] {ECO:0000313|EMBL:CDQ04559.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ04559.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ04559.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ04559.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm2052b.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
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DR EMBL; LN856475; CDQ04559.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1P6BTQ0; -.
DR EnsemblMetazoa; Bm2052b.1; Bm2052b.1; WBGene00222313.
DR WBParaSite; Bm2052b.1; Bm2052b.1; WBGene00222313.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR CDD; cd15720; FYVE_Hrs; 1.
DR CDD; cd21387; GAT_Hrs; 1.
DR CDD; cd03569; VHS_Hrs; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR017073; HGS/VPS27.
DR InterPro; IPR024641; HRS_helical.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46275; HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE; 1.
DR PANTHER; PTHR46275:SF1; HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF12210; Hrs_helical; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036956; Hrs_Vps27; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50179; VHS; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 12..140
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 157..217
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 356..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 240..274
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 480..524
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 356..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 803 AA; 90228 MW; 9671D46957500AD7 CRC64;
MAKRFERQLD KATDSTLIDP NWDAIIECVD LIRGGEVPVK AAAAAIRKRY HNENPHVAHH
ALLVLEACMK NCGVKFHAEI ATRDFMEDLK NLSLDTTPDK VKNKILELLQ CWALAFKNKP
EYKIVVDTHN LMKLAGFDFP HVAEADAMFI AESAPEWADG EECFRCRTAF GIITRKHHCR
ACGQIFCDRC SSKQSFLPQY GIEKQVRVCD GCYEKTATKK TDVSCSQSLV PLSSKVDKSS
VDAQKTAEQR ARELKQAEED EINLAIALSQ SEAEAQERER QRRLYELYNG TDNLNDVKSN
GTADNGELNK SVYKGAAPSI GGDTPISSGA AYVDPELARY LNRDYWQQRK NEQLNAVSTN
DCHQKVSTPT APPPSESSRC APSHDRDGTV SFAAPSFAST TKQLESDTTA ASHFISAEEE
ETAETMEFCR QLVEQVTVMD NRIRSNVARN RSVVNDTAIQ SLFIRLTEMH AQVMARMNKL
EDQRNHFESL QDSLAHIQEA RQAIDALRED HERQKQARIM EEQRLKQIQM QQKVDLMRQK
KHEMILHQRQ LALLRFQQQE REMQMKRMQM MRQTAQMNPA GYPPTAYVDQ AQLSYGLPIT
AAAQSYPSGA HMVQDNITAA TVKQGSNIAN YASIHPYADQ GSLGVQRLQE QQQSDISTSN
YQLNAAQYSS QLAANNTPTY SVASQSSVSR AYPIYQQQLE PAVTLPGGQQ QQQIQATAAN
IGLQKLTPQE QHKPSFIPST TVPATLNQHN RIIQPFSPYS LSNEMILEQP VQNIQYSMQP
QTNGEPQSQP TTQPAEELLI SFD
//
