ID A0A1P6BTZ8_BRUMA Unreviewed; 938 AA.
AC A0A1P6BTZ8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=BMA-PTR-1, isoform c {ECO:0000313|EMBL:CDP93670.1, ECO:0000313|WBParaSite:Bm2336.1};
GN Name=Bma-ptr-1 {ECO:0000313|EMBL:CDP93670.1,
GN ECO:0000313|WBParaSite:Bm2336.1};
GN ORFNames=BM_Bm2336 {ECO:0000313|EMBL:CDP93670.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm2336.1};
RN [1] {ECO:0000313|EMBL:CDP93670.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93670.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP93670.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93670.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm2336.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; LN856891; CDP93670.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1P6BTZ8; -.
DR EnsemblMetazoa; Bm2336.1; Bm2336.1; WBGene00222597.
DR WBParaSite; Bm2336.1; Bm2336.1; WBGene00222597.
DR InParanoid; A0A1P6BTZ8; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IEA:EnsemblMetazoa.
DR GO; GO:0090597; P:nematode male tail mating organ morphogenesis; IEA:EnsemblMetazoa.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR PANTHER; PTHR10796:SF191; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 840..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 315..453
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 938 AA; 108027 MW; FB6B61A8325A5CD5 CRC64;
MLSFDNIIQQ LFYRWGSIAY RFRFILFIGP ILLTIALSFG FLFIKRQTTI DPEYVFSPKN
AQWRYEKKVL SDYWPLNEQE FWPGKSYDYT GYVDIIAAGI KHPKFGRPNM LVLKYLDELE
RINQHIIHNI TISVTHNNMT YEVGFTDLCM SYDWKCFMNE HVTMLMPKER WGNFDPKLAE
FTDDIINNEV KITYPIGWRG TEPIYFGALI GAPHIIDKEG HFNYVRAVRL TYNVRDEKIG
NISYLWRKKV AGFLSDVKNP ASNILEFGMF HNESLPEGLQ QVADSLSPKF AITGVVLFSL
CGLSAIVLYK HNDGFIAVDW LRSKPTIALA GLFCPLLAII SAFGLILWMG FLYNAIVNVS
PFIIFCIGVD DMFIMSAAWH RTNVEQSVSH RLSESLAEAA VAISITTITD MLTFGIGCLT
TLPSVQMFCF YTFMGIAFTY LYQLTFFTSV MAYSGKREGD GLHAITLKPV ISEELADNLF
KKLFLTGSIS SKSTISTNNN TSSKIPSEFV QENVTGNEEN VKITLSQKMR EKFMDFKQSL
NKELPKSKHR ETMISKIFRE YYGPFLLDCF TKKVFIFIYI IYLSLAILGC TMLKEGLNPK
FLVLDSFYLS KFYILMDETF WEEGLQMQVV VNSPPDLFNS KERKEFQNML DDFENTEYTM
RHNATMIWLD AYERKLREDH NFSKIPLPKT SQEWYERCRE WLISAGGRRL WEKDMVWGKN
ESDPKTYNHL FAFRFQLGLR NYKTPTDHMR SAILMREISA KYAKFNITTF HEYYPFADQY
IELKPALIRN CLLAMLSMLI VSFIMIPSWI AAFVIAFAIF SIDIGVIGFM TFWGVRLESV
SIITVIMSIG FAIDLSAHIG YAYVKSSGNR HEKAISALET IGWPVFMGAL STVLGILVLA
TVQAYIVQIF FKTVFLVIIF SMIHGLILLP IFLTIILK
//
