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Database: UniProt
Entry: A0A1P6BZ30_BRUMA
LinkDB: A0A1P6BZ30_BRUMA
Original site: A0A1P6BZ30_BRUMA 
ID   A0A1P6BZ30_BRUMA        Unreviewed;      2186 AA.
AC   A0A1P6BZ30;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   05-JUN-2019, entry version 18.
DE   SubName: Full=BMA-GON-1, isoform e {ECO:0000313|EMBL:CDP93015.1, ECO:0000313|WBParaSite:Bm3594b};
GN   Name=Bma-gon-1 {ECO:0000313|EMBL:CDP93015.1};
GN   ORFNames=BM_Bm3594 {ECO:0000313|EMBL:CDP93015.1};
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm3594b};
RN   [1] {ECO:0000313|EMBL:CDP93015.1, ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm3594b}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CDP93015.1,
RC   ECO:0000313|Proteomes:UP000006672};
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J.,
RA   Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D.,
RA   Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M.,
RA   Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H.,
RA   Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J.,
RA   Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F.,
RA   Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J.,
RA   Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W.,
RA   Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
RN   [2] {ECO:0000313|EMBL:CDP93015.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CDP93015.1};
RG   WormBase Consortium;
RA   Ghedin E., Paulini M.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:Bm3594b}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JAN-2017) to UniProtKB.
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DR   EMBL; LN856865; CDP93015.1; -; Genomic_DNA.
DR   EnsemblMetazoa; Bm3594b; Bm3594b; WBGene00223855.
DR   WBParaSite; Bm3594b; Bm3594b; WBGene00223855.
DR   OMA; HCDSGPC; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016477; P:cell migration; IEA:EnsemblMetazoa.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:EnsemblMetazoa.
DR   GO; GO:0008406; P:gonad development; IEA:EnsemblMetazoa.
DR   Gene3D; 2.20.100.10; -; 16.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR041645; ADAM_CR_2.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR012314; Pept_M12B_GON-ADAMTSs.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF17771; ADAM_CR_2; 1.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF08685; GON; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 16.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 18.
DR   SUPFAM; SSF82895; SSF82895; 17.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS51046; GON; 1.
DR   PROSITE; PS50092; TSP1; 17.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006672};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00117091};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     58     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      369    582       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN     1975   2176       GON. {ECO:0000259|PROSITE:PS51046}.
FT   REGION        1     49       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1P6BZ30}.
FT   REGION      291    318       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1P6BZ30}.
FT   COMPBIAS     13     49       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1P6BZ30}.
SQ   SEQUENCE   2186 AA;  247547 MW;  2F01356D2E144FD7 CRC64;
     MLEVETSASE PLILHPDINN NNNSNNNNSN DNNNNNNDNN SNFDSDSNSS IDSQKPEYFV
     AIVFALAVLF SSLYLRGLSF TRIPQSRNRL IAAAVTDAKL QDGEVWHINR HQTRRRRSTW
     NDAKWHGVRG LARDCGFTCY FRLRQDTGDR MSKSELHIHL TRWKQLPQPN NKSLPMLENN
     RIRPIVQFMD SLDATHARMS RFVPDCLYSA HVKGATESSI VNLCDISGGL FGTLALPDGT
     YLIEPVKDDQ MPSKSSSSRA HIVYKSRSHS FHKYGFHSSS AAIITTTPSL NTASATTSTN
     SHSTSNHRSN NNNSTNDVQT HNYTAYRISN DNANYDNNTA QYTTIFDPNI NITDSSFARS
     RRSANSWDHY VEVLVVADNK MLLYHQNNLE NYVLTLFSTV ASIYRHPSLH AAINIIVTRL
     IVLKHETAGP HISDNAQDTL QQFCRWQETY NDKNDDAPNH HDVAILLTRH DICRAPGKCD
     TLGLAELGTM CDSLRSCAII EDNGLSAAFT ITHELGHIFN IPHDDERKCG RYMALNKHNY
     HIMAPTLEYN THPWSWSPCS AAMLAKFLDA NRAQTQCILD QPIERRYYDR MFEDPAPGAM
     FSANQQCQFV FGPSAELCPY MPACRRLWCA TYYGYQMGCR TQHMPWADGT PCGDNQWCHR
     GECVGMAPQQ RAKLDGSWGE WKNWGDCSRT CGGGIQKALR DCDNPRPING GKYCVGQRER
     YRPCNIQDCP WDTPGFREVQ CSEFDNKDVG IHGVPPKSRW LPKYTGVSDN ERCKLYCRIS
     GSAAFYLLKD KVLDGTPCYR HGDDMCIDGT CHKAGCDHRL GSEMRRDKCG ICGGDGSTCR
     VVSGSYNERG SFGYNEVLKI PAGSANIQIT QHGYGNQKED DNYLALRNAN GEFLLNGHYQ
     VSVFRQQISI QDTVLEYSGS DHVIERINGT GPIRTDIYLH VLSVGNLYPP DIHYEFMVPA
     QNVRFGYETS VTNYYWRISE RWSECSSLCQ GQQKQELICV DAISSRSVTD NLCISHRPPT
     ETRMCNIDCT IKWRVVPVGQ CNATCGRGEK HQKSECIRSY VDGRETIISD SQCHQLKKPS
     DRAPCYVDCA GRKWTYTEWT PCSESCGISG ITRRQAFCSD QTNRRLDDRA CEQAMKDKTE
     KECNRIPCPK WVYGEWSECS RSCDGGVKVR HASCQDAAGR EVHLTMCNSK EKHDWEKCNQ
     QICTQWRFGT WGSCSVSCGD GIETRDAVCT DLNSRHLDEN LCDRRERIVQ KPCHRMACPS
     WRLGTWSACS VSCLDGWKTR HVSCVDANDN EVSDEQCLRQ GEARPQSHQP CNQGPCPFWR
     ASDWTKCSVS CGVGVRARNV ECIYRDQVVD GSLCSDTQVS KVEQCSLLPC AKWKVLPWSH
     CSVTCGTGQQ TRTIHCLRGK SIVHESECDM AIRPKTEKVC ERDNCEAFTQ NVVESTVSDQ
     PKIRWAIGPW SDCSRTCGNG TQRRLIVCRD HIRDLTDTYC QHLEPIETYR YCQIKPCAQW
     TVGPWKSCSV TCGMHATTDR RVSCESMEGN EQVRETDCDL TNRPQSIRSC NLNPCPMGEP
     PLGFWITKEW EKCSVSCGGG WRRRLITCST RFCNEGEKPE QFERCNQQGC VKVSKVWQMS
     PWSHCPVTCG GSVQKRTVWC EDEKIRERVQ DTECLLPEKP STVRECNKIE CQMIPMKNEY
     YHWYAGKWNP CSTTCGRGVR KRIVSCVNSH SHSVASKYCD PAKRPIDSHR CRMTHCPRWK
     TGKWSMCSVT CGRGIRTREV TCQKGRRTHL SDMECGKLPK PLENSMCMTI SCPAYHWTAT
     PWSKCNDPCK KSDQHRRVYC VSNLGKRAAP KMCSNETAPE MTRSCPVTDC LYHWVPGPWS
     TCSKTCGTGF QFRRIECRVR SQNHSLSAEP NVQSRMCNGL TRLSVSKECA MNPCDAKYRW
     SVGPWSQCST SCGPGYRRRR VRCLDRDGRR VSRDLCDQSP DRPKRRESCF LRNCLPGDCA
     ELKAYYMQEN SVDGNYTVLV AGFRITVYCH LMNETLPKTY INLNSETNFA EIYGKRLLYP
     FTCPHNGQRN DTCMCTDDGS ASAGFSSFSK VRVDLHNMKI NIHDHTFATT SHGEEVAFAT
     AGDCYSAVDC PQGQFGIDLR GTGLRVMDDL RWVDQGHRTS SRIERSDNNA RIFGRCGGYC
     GQCSPDKFKG LVIEIDHKQN PSIGVG
//
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