ID A0A1P6C1H5_BRUMA Unreviewed; 1157 AA.
AC A0A1P6C1H5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Bm4523, isoform k {ECO:0000313|EMBL:CDP93349.1, ECO:0000313|WBParaSite:Bm4523b.1};
GN Name=Bm4523 {ECO:0000313|EMBL:CDP93349.1,
GN ECO:0000313|WBParaSite:Bm4523b.1};
GN ORFNames=BM_Bm4523 {ECO:0000313|EMBL:CDP93349.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP93349.1};
RN [1] {ECO:0000313|EMBL:CDP93349.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93349.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP93349.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93349.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm4523b.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
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DR EMBL; LN856868; CDP93349.1; -; Genomic_DNA.
DR EnsemblMetazoa; Bm4523b.1; Bm4523b.1; WBGene00224784.
DR WBParaSite; Bm4523b.1; Bm4523b.1; WBGene00224784.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR031354; BRD4_CDT.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF225; BROMODOMAIN-CONTAINING PROTEIN BET-1; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF17105; BRD4_CDT; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 127..199
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 373..445
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 758..839
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 535..572
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 127262 MW; CF83E6D0F6F2E885 CRC64;
MSLSAASTSN ANNSSNEPVT TSGSTLGVSE NPSVSDEKAS VDTENIQIEG SQNGEDASSE
QHVDDGDNDD SATDVGTAVP SINGWESPRQ EAINGVVQPR VIPPPGKPTR HTNQLEFMLK
EVLKPAMRHK HAWPFMKPVD AVRLGLPDYH KVIKRPMDMN TIEKRLRNCY YYSAKDCMQD
FESIFSNCYK FNQNEDDVSL MCKNVENLYR EKMKLLPSQE VEIPRPTAKR AAGKSKKSTG
RIAVVKGGSR ESSVSVQRGA ADSSSILDAA ANGAVHATAS TVDDVHPTSS QAPVQPVLPS
KVQKGVKRKA DTTTSFGDDV ISAKIATRRE SGRPPKKPNY FIDYNQLKPR FKGKQTEQMK
FCQRLVNELF TKKCKSFTWP FLEPVDVEGL KLEDYYDIVK NPMDLGTIRR KLDAKQYATP
EELRADVILV CENCYKYNPT SDPIHQHGRA LQKYFEDKWR QMPEEPLTVD EGTTAVQVVA
TAIPAPVSHV VPSAHAVTSA SAIVKDESVV SGLPLVPLDV SSGVIDSDEH IDLILLALQT
ETAKCQEKIS ELQRHSQEIL SLRLKRREAQ ANHLPVPVLS AATVGTLQSL VSTQFSFIAS
SPTPMLKPST AYPASSGAIP VSRKKPGRPA RTYQQQPSGL PTGLRTNNVT AEISPQDREL
KHEVNSPLSK ASVHQRQVQN SVHVSSPGVR SATAVPPQGT PQKPPEQSVP ASVARKRGRQ
PGSKNKPKTD AALSGTTVSD APPRQSGSRR VREDYDFDSE DERTAEPMSY DEKRQLSLDI
NKLPGDKLSS VVSIIESREQ LPGFNPEEIE IDFETLKATT LRELEAFVAA CLKKKPRKPY
TPKSQKEVEI KKRELEEKIK GLGGVITATP VTVAQNGARA EPTTTGKGEP SSSESSSSED
DSSSDSSSSD SSDSESETTG NAKAEHQGQH VGAEKSQDVD HSTEKKETSS AVPSTNSQQQ
QLGSVLQHPA NHFQMGNVKE EQKDSGSGTL PVAEDQLINV NSSSAISVAS QLQQTQSQIS
GGSILDQLLP AKQNEMEDKT GVKKLAGWDS LAKKSQSGSL NMQTSTQFEL FRKHAREKEE
KRKQLRVEEE RRRRLKEQEE RERAKDQAAA ETAELEQRRQ NELLRQKEQE RRRREAMSTG
GDVTSQMDLM LNFEANF
//
