GenomeNet

Database: UniProt
Entry: A0A1P6C2R4_BRUMA
LinkDB: A0A1P6C2R4_BRUMA
Original site: A0A1P6C2R4_BRUMA 
ID   A0A1P6C2R4_BRUMA        Unreviewed;      3515 AA.
AC   A0A1P6C2R4;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   03-JUL-2019, entry version 17.
DE   SubName: Full=BMA-EPI-1, isoform v {ECO:0000313|WBParaSite:Bm4903b};
DE   SubName: Full=BMA-EPI-1, isoform y {ECO:0000313|EMBL:CDP94695.1};
GN   Name=Bma-epi-1 {ECO:0000313|EMBL:CDP94695.1};
GN   ORFNames=BM_BM4903 {ECO:0000313|EMBL:VIO86870.1}, BM_Bm4903
GN   {ECO:0000313|EMBL:CDP94695.1};
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm4903b};
RN   [1] {ECO:0000313|EMBL:CDP94695.1, ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm4903b}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CDP94695.1,
RC   ECO:0000313|Proteomes:UP000006672};
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J.,
RA   Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D.,
RA   Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M.,
RA   Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H.,
RA   Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J.,
RA   Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F.,
RA   Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J.,
RA   Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W.,
RA   Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
RN   [2] {ECO:0000313|EMBL:CDP94695.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CDP94695.1};
RG   WormBase Consortium;
RA   Ghedin E., Paulini M.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:Bm4903b}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JAN-2017) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:VIO86870.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:VIO86870.1};
RA   Howe K., Paulini M., Williams G.;
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; LN856931; CDP94695.1; -; Genomic_DNA.
DR   EMBL; CAAKNF010000196; VIO86870.1; -; Genomic_DNA.
DR   EnsemblMetazoa; Bm4903b; Bm4903b; WBGene00225164.
DR   WBParaSite; Bm4903b; Bm4903b; WBGene00225164.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR010307; Laminin_dom_II.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR000034; Laminin_IV.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   Pfam; PF00052; Laminin_B; 1.
DR   Pfam; PF00053; Laminin_EGF; 21.
DR   Pfam; PF00054; Laminin_G_1; 1.
DR   Pfam; PF02210; Laminin_G_2; 2.
DR   Pfam; PF06009; Laminin_II; 1.
DR   Pfam; PF00055; Laminin_N; 1.
DR   SMART; SM00181; EGF; 9.
DR   SMART; SM00180; EGF_Lam; 22.
DR   SMART; SM00281; LamB; 1.
DR   SMART; SM00282; LamG; 4.
DR   SMART; SM00136; LamNT; 1.
DR   SUPFAM; SSF49899; SSF49899; 4.
DR   PROSITE; PS01248; EGF_LAM_1; 9.
DR   PROSITE; PS50027; EGF_LAM_2; 21.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 4.
DR   PROSITE; PS51115; LAMININ_IVA; 1.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006672};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW   Repeat {ECO:0000256|SAAS:SAAS00814929};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19   3515       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010662761.
FT   DOMAIN       17    291       Laminin N-terminal. {ECO:0000259|PROSITE:
FT                                PS51117}.
FT   DOMAIN      292    350       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      351    420       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      421    465       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      466    512       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      513    558       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      559    609       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      610    650       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      651    695       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      696    750       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      751    803       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      804    850       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1398   1443       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1444   1488       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1489   1536       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1537   1587       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1599   1780       Laminin IV type A. {ECO:0000259|PROSITE:
FT                                PS51115}.
FT   DOMAIN     1814   1863       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1864   1921       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1922   1974       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1975   2021       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     2022   2068       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     2069   2116       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     2681   2874       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2886   3055       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     3061   3225       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     3309   3482       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   COILED     2281   2308       {ECO:0000256|SAM:Coils}.
FT   DISULFID    316    325       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    388    397       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    441    450       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    466    478       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    468    485       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    487    496       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    513    525       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    515    532       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    534    543       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    559    571       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    561    578       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    580    589       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    626    635       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    651    663       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    671    680       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    721    730       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    774    783       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    804    816       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    806    823       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    825    834       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1398   1410       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1400   1417       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1419   1428       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1461   1470       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1512   1521       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1537   1549       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1539   1556       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1558   1567       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1833   1842       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1892   1901       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1946   1955       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1958   1972       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1994   2003       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   2042   2051       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   2069   2081       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   2071   2088       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   2090   2099       {ECO:0000256|PROSITE-ProRule:PRU00460}.
SQ   SEQUENCE   3515 AA;  391360 MW;  63BA3086CE6AF8D6 CRC64;
     MLPVLLLIVA AKTSFTCGQV LVPPYTNLAL DRKIEASSTC GELNGQPMKE IFCQIAGSSQ
     YTPLNQYSYS TGEDGVSVFA ELKMEKQSFV QGGQICDFCQ SNSSFAHPAR NMVDGRASWW
     QSPPLSRGIQ YNQVNISINL EQEFHVAYVW IQMANSPRPG SWVLERSIDG GKSYMPWQYF
     AETPAECDRL FGRHTLQPIL EDDSVICTHE FSGIHPMENA EIMINLLENR PGKHNFSHSE
     ILQNFTRATN VRLRLLRTKT LHGHLMDVNR RDPTVTRRYF YAIKEIFMGG RCVCNGHADT
     CDILDIRRSN ILLCRCEHNT CGDHCEFCCP GFEQKMWQRS KEGAEFVCEP CNCHGHSEEC
     VYEKELDRMH SSLDIHGNYD GGGRCLNCRD NTEGINCNKC IFGYYRPKTK WWNETDVCQP
     CVCDPAKHTG NCEDETARCV CKPQFTGVNC DRCAPGHYSP PNCKPCDCSI NGTLDDICLP
     VNGRCPCRSN YGGEFCQVCA PGYTNLSAGC ISCNCDELGS LHNNCNESTA QCMCKTNFAG
     LTCDSCADGY FGHSQCKYCD CDTIGTEDSI CDKVTGACLC KPGFSGSRCD ECSLYFYGYP
     FCRECGCNKH GSKSAKCDRK NGDCPCYANF TSKNCDRCAA GYYDFPNCKP CSCMAIGSKG
     MTCDNNGQCY CKKNFQGERC DQCKTNFYNF PICEECNCNP KGVVAGFAGC DKVEPGELCT
     CKTHVTGRIC DRCKPTYWDL QYHHEDGCVQ CDCNLAGTLS GLNECSIEVG QCNCKRHVVG
     RRCDKCADGF FQLEVHNQFG CQACNCDIGG ALGIGCDMQT GKCRCRPRIT GQKCDRPIEN
     HYFPTLWHNK YEAEDGISME QNAVRFTTDK NKFPNYSWRG YAVFSPIQED ILLDVAISKA
     SLYRLLFHYI NPTDVQIDTR IAIMPLFTHT QDVEQKTRLN LPSTSEPTTI AVNPQQPFIL
     SPGKWRIKIS TKQRLFLDYI VLLPSEYYEG TVLKERIFEP CQVTGSQNTT CLELLYPPLP
     TMSRANIIEY GLITEEQNDS STQRVEKILI ENLFTSTNEA AFVQTNNESR KIRISLKVPE
     NNYYILLMEY YNADSAISLG LEMRQYDQLL MKKNIIFKHC PYSTFCRDIV SSDEGIALMH
     LKDGGDVEIT LIVGPKHKFS LAAVNLIKME DWDITYLQQV PVCIRKNGHC VTQWFPFVAN
     GMLNEAESQI NANNSIIGEK LPFIIANPKE VQVIALDGNM GTVEVSGVVP SHGDYVFIVQ
     YFNPDNTLLT VDVTLQNGHL HHAEISFSYC PSVIGCRAVI RDKERRDVIQ FFVDDKYTAS
     FYFNENQKGP LFIDSITSLP FHSYSDTLLI PLPIDISVQY IQECSFNNFK NDPSNVSEYC
     RQKVFSLTSE HNMAALPCEC NSQGSTSFTC EEYGGECSCR SNIIGRRCDR CAPGYYNFPD
     CIKCKCPDNH LCDENTGQCF CPPHVEGKHC DSCVPYAFGY DPLIGCQLCG CQQNGSEARQ
     LQCDPDSGQC LCKVNVGGRK CDKCLPGFYG FPHCYECACE IEGTTEEICE STSAACKCKK
     NVIGENCDIC RPGTFDLRAS NSDGCSECFC FGATDRCRSS FLPITFVNFD EEAWKIYPNE
     SVLHTHGKVV YEAKIDAKDD VYFLAPIRSG HDYTTSYGLQ LSFVVLSNPR DGETKMNSAP
     DVQLVGNNTV LDFWAREQPV NPRIPFNVDI ILLPENFMES TGEPTTRDTL MMVLHGLDEL
     RIKACYYTNC ELASISELQL EIAKDDQTTS DSYTASSVEI CQCPLPYTGL SCQQCSPGYY
     RVNNGRYLGS CVSCNCNGHS GSCDPSTGIC FNCEHDTFGD HCEFCRVGFY GDATKGGPYS
     CMPCACPYAT NSNNFATSCQ VSETGLLESC FCKEGYTSDY CERCDIGYYG QPTAIDGSCH
     KCNCNNNNNL EVDGSCHPIT GDCYLCLNNT DGAHCEHCKP WFYGDAVEAK NCTNCACNQC
     GSSLCDSRSG KCECLANVEG EKCDRCVTNA WGFIRCHGCE MCNCALASSS PQCDAETGQC
     SCMPGAAGQM CEICEYGYWN YGPTGCSKCD CEADLSMGTV CDVNTGQCHC QEGATGPRCD
     QCALHYVRIP NLGCRLCDEC VHSVTHDLDK LTDAVALVNE TVNNISTTAL TGARLKRIHK
     KINDLKPIVV NHMNSSSDVD IKSLSSSGIL DTTSNVVSVI VRANRSLDTL STMGSTLNGI
     INRTNIFLSG VFNRVESAAS VVDSLKNLVF SLGKDSGAVY NQKWLMNSNS LLQKIRDSAN
     DEDARKRMKD AEDETQKLLS RIRQLKNKDN VMYTKYFTVR NQMDRLMNNI TDYHSFLYRA
     ANSVENTLQQ VNNSNIRHIN SVQAGVKAGG VRIRETHAFI NSLKETSEIS IESLSNLNKT
     LREVISEVQV VFGQLNITNG RYRHRWIRNI NKNEYRGKSK ELESEALFLS SLFGRTRTEA
     KNAVAAANGY KELIEHLKKA RDVANHTSLN AEQARRFHEE GVAASARTFR EQSADLLRSA
     VDLKQSSVNN VGGLKDIFLG KALELQFFIE NQKRILDSLH PKFDDLEVNA KLEHSLTASE
     EARTRTDSTI FLFDRFKPNL EEMVSRSKKL VESISLSANN VDTAREQILK LVNESSPIME
     ELKMQQHAAL NISATIEHCR EKLNLLKEKI ALSRDLANRI NLGAHFEKGS ILELPLPPRI
     TRFAAYTDID FFFRTTNTSG LILFFGNELG VAGTRAVPTD DYIAVEVVRG HLRIVVNLGE
     TPTQLISDSF VTDGNWRKVA VERVGKTIKL RLSSPSSVNY EEEKARTIGG FKSVLNLHQK
     KSRLFIGGVV PGVNISPEIH NREFTGDIED LRIHGETVGL WNAKKGGNYN VKGAMKKIFA
     TSLTNEIALS FNGDGYAVYK LGIWNPRKQT IFSLTFQTYS PDGLFIYLGK ERGFLSLELQ
     DGRVKLSFDF GSGVARLTST GNNYNDGKPH CLYVHRLERH ARMQVDDSDV SEGDSPGTMF
     ELSLSDVFYL GGVPSDVSTR TAVVSMNGCI EQVKLDNRLM DLSKSRTARG VQLGCSARNV
     RVVSMVSERS IATFSGFNVK EDYLELTFRF KTKRSSGILA SVISDEQEVL LQLRYLNGFI
     LAEYGSDNKD VAQIEFRSIA DGHWHYLASI VKPETIRLDL DDLYSNEIRR SVADNEVVGV
     PIIVQFGQSL DSNLYFEGCI GDATYNGQLL DFAEASTNEV GLTDCSFLED ISTTDMSSGQ
     ATRNQPMNVS IPATNSMQPV VTETDNEFTA ENRISSDTPS LTTLRGIVRK SDECALLKRS
     YGNRPNSSGT RFGLSPSSRL EFDKPPSSFD KNSLFSIQLR ATASNGIIMF TTNNRHTDYL
     ALYLVNGIVH FAYNSGSGQA VLKSNRSVMD YEWHSIRAER EGLAGTLYID NVMEANGQSP
     PGTDTVDTQP PIYIGGLPTD LVPFASRILQ GAKSVFGGCL RDFKLNEMKF DVPPVEIGTV
     PCSHYTEEGL YFGENGGYAV LNKNLKAVTW SSETG
//
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