ID A0A1P6C2X4_BRUMA Unreviewed; 523 AA.
AC A0A1P6C2X4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 13-SEP-2023, entry version 25.
DE SubName: Full=Bm4941, isoform b {ECO:0000313|EMBL:CDP94636.1, ECO:0000313|WBParaSite:Bm4941a.1};
GN ORFNames=Bm4941 {ECO:0000313|EMBL:CDP94636.1,
GN ECO:0000313|WBParaSite:Bm4941a.1, ECO:0000313|WormBase:Bm4941b},
GN BM_Bm4941 {ECO:0000313|EMBL:CDP94636.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm4941a.1};
RN [1] {ECO:0000313|EMBL:CDP94636.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP94636.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP94636.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP94636.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm4941a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; LN856931; CDP94636.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1P6C2X4; -.
DR STRING; 6279.A0A1P6C2X4; -.
DR EnsemblMetazoa; Bm4941a.1; Bm4941a.1; WBGene00225202.
DR WBParaSite; Bm4941a.1; Bm4941a.1; WBGene00225202.
DR WormBase; Bm4941b; BM47553; WBGene00225202; -.
DR InParanoid; A0A1P6C2X4; -.
DR OMA; WVYWGIA; -.
DR OrthoDB; 239997at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF80; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2, ISOFORM A; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR PIRSF; PIRSF016379; ENT; 1.
DR PRINTS; PR01130; DERENTRNSPRT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 46..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 523 AA; 59870 MW; AE42D242E524CC6F CRC64;
MKLLVLSQVI YTEMKLLISE CRFSFCTTFL NIAVYDSGMI FFQRQFFYAI FYVNASELIG
MILDKPPKDK YNAVYFILLL HGIGVLMPWN MFITIAPSYY VDYKFVEVSA DGMVHKSDYA
LHFLSYLGLA SQIPTLLLNL INLFVQIKGD LRRRISFSLL ILAIIILVTL IFTLINTSHM
ISAFFFITMT TVVLLNAANG VYQSSLYGLT ANFPPQYTNA LILGNNICGT FVSVVNIVTL
VVAKSVWMAA FFYFLMSLLT VSACFGSIFL LEKLEFYEYH MRKTQKHGDK NEHEEGQHLE
RINTVDGATM DGTEMIGVVP KAGLKAKLKL YFQVFKKIWI QCFNVWCVFF VTLAVFPVVM
ADIKYYSKSG KYDFFIAEKL FTPVTTYLLF NFFAAAGSFL ANFVQWPSPK WLIVPVTARI
ALIPLLMFCY FRPEYRTWNV WFYSVWIYII FAVIMSITSG YFSSIIMMYI PRIVEPSKST
VASMIAAFFL IFGITCGIMF TFFVSWFIDN AGVHNPGGFD TVM
//
