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Database: UniProt
Entry: A0A1P6C413_BRUMA
LinkDB: A0A1P6C413_BRUMA
Original site: A0A1P6C413_BRUMA 
ID   A0A1P6C413_BRUMA        Unreviewed;      3732 AA.
AC   A0A1P6C413;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   07-NOV-2018, entry version 9.
DE   SubName: Full=BMA-UNC-68, isoform i {ECO:0000313|WBParaSite:Bm4999c};
DE   SubName: Full=BMA-UNC-68, isoform k {ECO:0000313|EMBL:CDP99999.1};
GN   Name=Bma-unc-68 {ECO:0000313|EMBL:CDP99999.1};
GN   ORFNames=BM_Bm4999 {ECO:0000313|EMBL:CDP99999.1};
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm4999c};
RN   [1] {ECO:0000313|EMBL:CDP99999.1, ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm4999c}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CDP99999.1,
RC   ECO:0000313|Proteomes:UP000006672};
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J.,
RA   Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D.,
RA   Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M.,
RA   Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H.,
RA   Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J.,
RA   Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F.,
RA   Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J.,
RA   Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W.,
RA   Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
RN   [2] {ECO:0000313|EMBL:CDP99999.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CDP99999.1};
RG   WormBase Consortium;
RA   Ghedin E., Paulini M.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:Bm4999c}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JAN-2017) to UniProtKB.
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DR   EMBL; LN857010; CDP99999.1; -; Genomic_DNA.
DR   EnsemblMetazoa; Bm4999c; Bm4999c; WBGene00225260.
DR   WBParaSite; Bm4999c; Bm4999c; WBGene00225260.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006672};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN      104    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    209       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      333    391       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      570    791       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1008   1202       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1450   1661       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   3732 AA;  423069 MW;  527578D6DCBECBA9 CRC64;
     MTDKEGTGDG EQDDISFLRT GDIVAMTCMA SASREGVLGS ERVCLCTEGF GNRMCSLENV
     SDRDLPADIS MCMLYIDNAL SVRALQEMMS NDKELRGAGS GGGHKTLLYG HAVQLKHVQS
     EMYLACLSSC SSNDKLAFDV GVQENNEGEA CWWTIHPASK QRSEGEKVRV GDDVILVSVA
     TERYLHMTHS KGFMVIASFH QTLWNITSVS SGSVRIRNMG ALFGNDVLRF FHGNDEVLTI
     PENWSEHPQQ NMAIYEGGAA VSQARSLWRI ELIRIKWHGA LVGWEQPYLG VMENVIQLYD
     KDKAEFDTTA FVMYQTKDLK KQLLEEKEEG MGVATIRYGE TNAFIQHIKT ELWLSYQTSE
     TTKKGLGKVE EKKAVALKDG HMDDCFTFFM ALEEESKSAR VIRKCSSVLN RFLRGIEALQ
     REGKQAQDWN RVDLSEVLKL MEDLIDYFAQ PDEDDFEASQ NRLRALRSRQ DLFQEEGVLN
     MILDTIDKFS QMEAVRDFAG LLNEDTQMMW EEISTYLYLL VAAMIKGNHY NCAQFASAQR
     LQWLFGRLSN PQSAEGILDV LYCVLTESPE ALNMINESHI KSVISLLEKV GRDPKVLDVL
     SSLCEGNGMA VRSSQNTITQ YLLPGKDLLL QTKMRDHVSS MTPNILVGVV EGSSQFRRWY
     YEAEVEHIER MTKTEPYLRI GWANSMGYKP FPGSGDGWGC IGVGDDYYSY GFDGRCIYCA
     TKKHVIWTRT LQKGDVVGCL LDLNIPEISF TVNGQSTAGM FKNFNIDGFF FPVMSLSAKV
     SCRFMFGGIE GRLRFGPPPG FSALIEAAAN KLEIGECVSF GDIAKNVYTG PSILRQNTEP
     FVPKLVDISA VVLPHFAMEI HEKMAENLHE LWAMRKIELG WSYGEVRDEK TRRHPCLTSF
     QQLPPNEKAY NINLAIDTMK TIEALRYHMI LDEPPVRLRP VRLPQNYQQS NGFKPQPLDC
     HEIVLDDNMF SLIDALAKNT HNVWAREKIR RGWTFGLNEF VNISQKRSPH LVPYEVVDQR
     IKEANRESAT EFIKTLQLFG IFLESPVLEH DEGAEKELKV TKAFSRTYRA EALYAVSSGK
     WYFEFEVLTS GFMKVGWMDI SAQSTVDIGT DDRSYGFDGY LARKWHQGAG TYGREWKIGD
     IVGAFLDLSD HTISFSLNGE LLLDPSGSEM AFDNVLVTDG FVPAMTFSAG QRAKLNFGQD
     SNSLKYFTTC GLQEGYEPFC VNMYRQMPMW YAKRLPQFED IGLNSTIEVS RIPATGNNPP
     CLKITQKEID TGDMTAQEKA KMEYIRLSLP VKCNEKLQPT KDKESIMRSL HEIEKQLAEE
     AQPVPTIRHP AIPKEFGDDT KKSLGRSLLS AFKHSAEEDE SSARSKPISF DGDHHLAETS
     TIRMSGSMLE LSSTGEQRDG KHKRGGLMAR FHQRKKEGMS SENKRTTGML VDGHIVSVDT
     ISAENIPPSM SKDDQDMPQS GPGRSRRGLM GSDKWKKKNE KFLEHRRPSI AALEQSVIID
     GNVPSDDVRT MIELGDKIDE FYYAIRIFPG QDPANVWVGW VTPKYHFYAE RFITGEAIRR
     CKYQGTSENV NEGESLEYRN CYVVNAAELL QSVPEPGNTK VSGLLIGCII DTSVGELSFL
     ASKQDTGFRF KLEPGAILYP AAFVAPTSAE VLQFELGRIK YTFPLSSAMF KSSHKSLLPF
     CPPRLTVEKL NPVHWARVPN ECLRTTALKL SDFRGWSVLC DDPVRIMSIY IPEKDTSYDI
     LEMIEHNDLL TFHRQTLNLY CKLAAHGNQK VAHILCSHVD EDQILYAVKS HYLSGPLRQG
     FHDFLIAVHL RTYVNARQST THEYVIPLKQ NHEIKNVFHP EIEDRFPQIL GPTISIRPVI
     VCSEVRSNFG MDAESKLLPP AFNFVALKAH VMSALSSATE HAVISCRDLI GGNCLNHFEP
     LFKLFNALLV IGIFDDDDLK DVMKLIHPIA FDENYVPGLK QKGLTEIELA EGVKIQLTII
     LENICNIQLR HRVESLVSFA AGFVNDLQQD QFSRYMSIKQ TNMTPAEAAR RTKEFRCPPR
     EQMFRLMKCK AVPDDSIGIM LDDETEYDQC PMNETLQQQL RQFCSLLVGR VGCVKSEERN
     KLSELVILEE ANSWVDQLAQ LVIRVPPPFT GEDKSMNHNG TESFRLMICT MLKSWATSSV
     IESNELIRKM FSLLLRQYTG VAEMMKALSQ TYVLHERNIE DVQDFIENLV QVRELLSVQF
     ESAEEAILKR GLWKLMNNRI FFQHPDLMRL LTVHENVMSI MMNVLTAQQG ATNHGEHTEH
     VENMEEIVNA QDSKDASEMV VACSRFLCYF CRTSRQNQKA MFEHLSFLLD NATMLLARPS
     LRGSVPLDIA YSSFMDNNEL ALALKEEELD KVTVYLSRCG LQPNLELVAK GYPDIGWDPV
     EGERYIDFLR FCVWINGESV EENANLVIRL LIRRPECLGV ALKGEGQGLF SAFKEAIALS
     EDIRTLEENK NRAVIHSALL REQPHYPNKE TEGEDYVDLG AATLDFYSSL VDLLAKCAPD
     KINIQAGKGD CMRARAILRS LISLDDLGQI LALRFTIPNL ITSVATDDVG PLPGLLPNHK
     QSVLLFLDRV YGIDSQEMLF HFLEKSFLPD LRAATMMDSP CSVESDTALA LNRYLCNAVL
     PLLTSHSYYF ADAEHHAALL DTTLHTVYSM NHLRSLTKNQ RDAVSDFLVA ITRELPPPMM
     VKLMRKVIID IQEMDENLLV PLRILTLHYE RCTKYYGSGN IYGMASETEK RLSMLLFYAI
     FDSLGSKQYD PELFGKALPC LTAIGSAISP DYTLTTTGDD TDRIQKTKDR GIWNPDPVDV
     SEVHFDDDLK SVVAKFAEHF HDSWASRKIE KGWNYGELYS RQALTHPRLK PFVFLPDFEK
     NFYQERCAEC LRALLVWNYS IELTDRDAAD KAIQNNTSLG SSIENFNPKP VDLSNMTLEK
     DMTGIAEKMA EESHKIWAKK VLADLNRGGT MPPQLVPWDL LTDFERRKDR FRAAEILKFL
     QYHGYRVWSS NKPEPSAERV KIDSERSSVE KRFAYNLLKK LIQYLEQASL KMKTIKPSQE
     LTRQNSFRKE GQDVKFFEKV VLPLMHAYFN AHKNYFLANS SVVQTGMASD KEKEMVANLF
     CRLASLLRFK NHAFGNVAKI TVRCLQGLIQ SLDLRTLVKI NSDIVRTGLL TFFNNCADDL
     FSAVEELQNG GQYSLLRGQN LKSWVSLEFA NQMIIPVLTT MFVHLAINHF GSDLLLDEIQ
     AACYKILDSA YLLNSLAATT SQRKSIAYEM DKHRPALGQC LAAFAGCFPV AFLEDKFNKN
     NKYSLLAKSQ DQSVQVQEML QNLLAHIPQL DKLLTEVEQV GQSGAMYREQ PAAYDVDLPL
     ICSYLTYWWQ LGPDSSNRST VPVTDVGNEH INRIFRALLQ MIHNHIGVEN ASWLCRINFF
     SVQIIPYVSC DAVKDYMLPV AERLRRLAEK AYREEEHMRT HPDDADEGTV AEDNAHLVRD
     VYAYFPILMK YTDLHRAQWL KSPSWETDGV YENVAIIFKI WSLSQHFKRE ELNFMAQYED
     ESVAGGTGEM KTGKAAIAER KKKRREGQMR KDKHAGSIVI ACLKRLLPVG LNVFGGRELD
     IVQQAKEKFL AKEPEDKIRE LVRSLLDIPA KTDPTDKNAW QLNLYRKIGK SQMRNKDVMT
     LDGIVDKITS MGQVVAILHV TEHPQGSMVN AWKTMLSSQR KRAVVACFRM IPLYGIPRQP
     VSLKRRVDGN VS
//
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