ID A0A1P6C721_BRUMA Unreviewed; 4582 AA.
AC A0A1P6C721;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=BMA-DHC-1, isoform f {ECO:0000313|EMBL:CDP95784.1, ECO:0000313|WBParaSite:Bm5897a.1};
GN Name=Bma-dhc-1 {ECO:0000313|EMBL:CDP95784.1,
GN ECO:0000313|WBParaSite:Bm5897a.1};
GN ORFNames=BM_Bm5897 {ECO:0000313|EMBL:CDP95784.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP95784.1};
RN [1] {ECO:0000313|EMBL:CDP95784.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP95784.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP95784.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP95784.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm5897a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; LN856952; CDP95784.1; -; Genomic_DNA.
DR STRING; 6279.A0A1P6C721; -.
DR EnsemblMetazoa; Bm5897a.1; Bm5897a.1; WBGene00226158.
DR WBParaSite; Bm5897a.1; Bm5897a.1; WBGene00226158.
DR OMA; NERQMTR; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 1863..1998
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2166..2317
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2540..2690
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2883..3044
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 528..555
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1563..1590
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3180..3235
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3356..3418
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4582 AA; 523452 MW; 7D9C6841FF13D409 CRC64;
MTDSESDKST VATTTPAAGE VALVDIPILL DYVKHEFIGA GSAALKEALS QSANAECVQK
FISDPQVQML VVDRVVTRDT NPDDAVEDVT SVFRISNEIA KRTERTTSLL LLKSGTYIEA
DKPIEDQLYV IRIPEGNSYD VLLSIFGRIG TPLFKSLVDY GRGERDGDKL ALSVEKHLSE
VEVALLHMQQ NIDIPEINLT IHPVIQNAIQ QAAEKGHKAR VTDLGGLVES SVFLNALQKG
VNRWVKEIQK VTKLDRDAGS GTSLQEMTFW LNLERALQKI AQKRESDEVT LTLETLKCGK
RFHATVSFDA DTGLKQTLAM VNDYNVLMKD LPLNELMAAT NMDGIKNALA NIFTHMRKLR
NTKYPIARAL RFVEAISKDV LTQMLKTLGT RRLMNIPLGD FDSLMAQCFA VFSIWNDEYD
KLATLMRDLS KKKRDEQLKL TWRLNPQHKK LESRLDQMRQ FRRQHEQLRT VISRVLRPVG
QKGEKRSDSD VEKTSTLIAP ELSAIEQVNT AYENVKEVDC LDVSNDGTIA WEAAIRRYED
QIDRVETQIT AKLRDQLGGA RNADEMFMIF QRFNALFVRP HIRGAIREYQ TQLIQRVKED
IDKLQTRFKN FNEADNARIL RAIDIPPVAA SILWIRQIDS KLTQYMKRIE DVLGRGWENH
VEGRQLKLEG DNFRQKLNTQ HIFDDWVSRV QAKNISLTGR IFIIEKRQKD GKIALNLKVN
FSSDVVTLFK EVRNMKHMGF RIPLKIVNTA HQANLLYPFA ISLLESIRTY DSINERIANK
PGVNMLIVAY KKDIQGQLAE GNSLTWESYK MDPYVVKLSS SINNFQEKVE ELDILLDRIE
VDLAALDTCH YTSVTIGTLL DSIQKAVDQL SLGNFSNLHH WVNSTDAKIA KKLASRVEEA
IHLWTVVLAN DDFEDESDEK GTLPVLQPIV LEMRVTSQVM YVSPSIEQAR AHLLDQLFAW
QSVITNQPRI SSTRFQLTLT KDSTEATYRD VLAYLPQGQK IIEQAYYAVE KVMKEVTDYV
GEWLRYQALW DLQPDVLYER LGSDVSKWMK TLIEIRKSRA TFDTQETRKE IFPVVIDYTK
VQSKVSLKYD YWHREILQKF GSSVGQEMQA FFSDISKWRN ELEEQSVDSG TTTDAIQLIT
YVQQLKKKTK ICQDKVEQFR AAQRLLTQQR YQFPNSWLYS ENVDGEWSAL SDILERKDSA
IQAQVANLQT KIKEEDEIVE KRTQDVLADW DKCKPVQGTQ RPTEALLALA TFEAKLSKVK
EDRANMIKAK GALEMVEPVF TGGHAAKLDI AVEELSDLKG VWQSLMPMYD AVDELKEKTW
LSVQPRKLRQ SLDDLLAQLK QLPAKYRSYD SYEYAKRMLH NYSKMNMTIV ELKSDALKER
HWKQLMKELR VSWNLSELTL GQVWDADLLR YESAIKQVLL VAQGELALEE FLKQVREYWQ
SFEVDLVNYQ NKTKLIRGWD DLFSKLKEHM NSLTAMKLSP YYKQFEEDAL AWEEKLNKIS
ALFDIWIDVQ RRWVYLDGLF SASADINTLL PVESSRFSSI STEFLALMKK VTSTSRILDI
ANMQGAQRLL ERLADMLAKI QKALGEYLER ERNSFPRFYF VGDEDLLEIM GNSKDITRVQ
KHLKKMFAGI AAVDVEEDNT LITAMSSREG ERVRLMKPVN VKESPRINDW LRMIECEMRN
TLAHLLNQSL SIFSKFDMNS VGAEEYIAWL DQFPAQIIEL TANIWWCSNI EKHFAEGKTV
EVVEDIVDKT LSLLADSVLS EQPAIRRKKI EALITEFVHK RDICRSLIQN KVVSITSFYW
SRCMRFYFDP RKLDPDSCCF MKMADAYFPY GFEYLGLQEK LVQTPLTDRC YLTMTQALNS
RLGGSPFGPA GTGKTESVKA LGHKIGRFVL VFNCDETFDF QAMGRILVGL CQVGAWGCFD
EFNRLEERML SAVSQQIQTI QEAVRTGGQM QVDLVGKTLS VNSNMAIFIT MNPGYSGRSN
LPDNLKQLFR SLAMTQPDRQ LIAQVMLFSQ GFRTAEKLAK KIVPLFILCK EQLSDQCHYD
FGLRALKYVL VSAGNIKRDE IQRMIQSRSD INKSDISSEI SEQQILIQSV CETLVPKLIS
DDIALLFSLL SDVFPSIQFK PSQMDGLRSE IAKVCDQLLL CQSPIPGELG SAWLEKVLQL
YQITNLNHGL MLVGASGSGK TTAWKVLLKA LERLEGVEGV AYVIDAKAMS KDALYGVLDP
NTREWTDGLF THIIRRIIDN VRGETSKRQW IIFDGDVDPE WVENLNSVLD DNKLLTLPNG
ERLGIPPNVR IIFEVADLKY ATLATVSRCG MVWFGEEMIT CEMLFDNFLK RLRNIRLDIE
HSVDLLSLNV GSEEGAITPE AERVINLQRK CAHYLAQHMN ADALVPLTLK YALTELDHIM
VPSQQRMMSS FFSMMNYTVR QLINYDNAHP DFPMPDDQIE AYISRAMLVN IVWAFGGDSK
WKSRQQLSDF IRQSSTLPLP PNTALPIIDY EAAFSGEWVQ WVSKVPQMEV ETHRVAAADL
VIPTVDTVRH EMLLNTWLSE HKTLVLCGPP GSGKTMTLLS ALRSLQDMDV VNVNFSSSTT
PELLMRTFDH YCEYRRTPNG VVLSPVQISR WLVIFCDEIN LPLPDKYGTQ RVISFLRQLV
EMNGFYRVSD QTWVSLERIQ FVGACNPPTD PGRHPLSLRF LRHVPVVYVD YPGQTSLLQI
YGTFNRAMLR MAPSVRSFAD PLTNAMVDFY LQSQEHFTQD EQPHYIYSPR ELTRWVRAIS
EAITPLDSVN PEALVRLWAH EALRLFQDRL VRDDEREWTD HLLDTIAEKY FGTSCDLKQA
LERPMLYSCW LTKHYLPVSK EQLKEYVAAR LRSFYEEELD VQLVLFDQML DHVLRIDRIY
RQPQGHLLLI GTSGSGKTTL SRFVAWINGL SVFQLKVHSK YTATDFDEDI RTVLRRTGCR
NEKVCFIMDE SNMLDTGFLE RLNTLLANGE VPGLFEGDDY TTLMSQIKED AHRQGLMLDS
PDELYKWFTA QVMRNLHVVF TMNPSGEGLR ERSSTSPALF NRCVLNWFGD WTDSALYQVG
MELTNTLDMA LPEYQAPLTL PAVCDLLPSP VQYRHAVINT FVHVHNSVRK LNENEAKRGH
RVVALTPRHF LDFIKHYINV FHEKRRDLEE EKLHLNIGLS KIRETEEQVL ELQKSLTLKS
SELETKKAAA NAKLKEMLAD QQRAEKEKLA SEQLQKELAE SLVQIEKKRT EVQEDLAQVE
PAVEEAKQAV KGIKKGQLIE VRSMAAPPQP VRLALESICL LLGENVGMDW KAIRGVMVKD
DFMPRILNFD TDSISAETLK IMEKYIRNPD WDFDKVNRAS SACGPMIKWM KAQLLYSDML
RKVEPLRNEL ERLEKDAKVK TAKGEDLKKT IAKLEQSIAA YKEEYAQLIG QAEAIKADLA
TVKEKVGRST QLLGSLGSER DRWNGSCDGF SQQMDSLIGD ALLSAAFLAY SGYYDQQLRD
LLLQRWTAFV EQAEIKHRSD LARVEYLSSV DERLEWNKNG LPVDDLCAEN AIMLHRFNRY
PLIIDPSGQA INYLMKQFAG KNITKTSFLD DSFRKNLESA LRFGNSLLVQ DVESYDPILN
PVLNREVKRT GGRILIRLGD QDIDLSPSFQ IFLITRDASV EFAPDLCSRV TFVNFTVTRA
SLEMQCLNQV LRSERPDVDE KRNDLLKLQG EFAVRLRQLE KALLAALNES KGKILDDDSV
ISTLEKLKNE AAEVGRKAAE TNKVIAEVET VSQHYLRLAQ ACSLIYMMLQ QLNEVHFLYQ
YSLEFLLEIF MAVLVTPQLK SVTDYEQRLK IIMSNLFQMV YRRVSLGMLH QDKVLLALLL
MRIVLKGNSN ERSYQLEIDH LLGRSEIFTG QKQAEGVESL HGFSAQQMAS LFQLSRLPAF
TDIVKKVTST IDFRNWIMLD NPELNVPIIW NDDDKLTKIG RCINELLVIH AIRPDRLLAS
SHRLVAAVFG DEFMQEDKVV NLREIVENEV NANRPILLSS AIGFDASGKV EDLAVEMGRE
VTPIAIGSAE GFSQADTTLN SASKSGRWIL LKNVHLAPSW LAQLEKRLHS LKPHPQFRLL
LTAEIHPKLP PQVLRASRVV VYEPATGLKA NLLRSLSSIA PQRITKPPVE RSRLYFLVCW
LHAIVQERMR YIPLGWANSY EFSDSDLRVA CDTLDASVDA VAMGRANVSP EKLPWHTLRC
LLSQCIYGGK IDNGFDQMLL DCFLEKLFTA KSFDADRVLI SNIDGKGTDF CIPDGNSREH
LIYWVEKMHY LQLPYWLGLP NNAEKVLLTV RGETMLTNLL KVSDDELAFT GDDQKTQSPP
WMSVLAEQSS QWLKLLPTNI PKLKRSLENI KDPLFRFFER EVIHGTHLLA SVRNDLVEVQ
SVCRGERKQS NHTRALTLAL NKGLVPSDWL RYTVPKVVTV MAWIHDFAER AKQLIRLAGS
ASLKKESIWL GGLFAPEAYI TATRQTVAQS NQWSLEELRM HIEIGTIDDR PDTFRVEGLR
LMGAACKEKN KLEIVDEVST DLENVTLSWF REASSPSSIT LPVYLYRDRK NLLFTLDFDP
GEVQKTCLYE RSIALTSNSS LS
//
