ID A0A1P6C9W5_BRUMA Unreviewed; 1693 AA.
AC A0A1P6C9W5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=BMA-EEL-1, isoform k {ECO:0000313|EMBL:CDP92873.1};
GN Name=Bma-eel-1 {ECO:0000313|EMBL:CDP92873.1};
GN ORFNames=BM_Bm7004 {ECO:0000313|EMBL:CDP92873.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP92873.1};
RN [1] {ECO:0000313|EMBL:CDP92873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP92873.1};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP92873.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP92873.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN856865; CDP92873.1; -; Genomic_DNA.
DR RefSeq; XP_001897763.1; XM_001897728.1.
DR CDD; cd14288; UBA_HUWE1; 1.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041918; UBA_HUWE1.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR037197; WWE_dom_sf.
DR Pfam; PF06012; DUF908; 2.
DR Pfam; PF06025; DUF913; 1.
DR Pfam; PF02825; WWE; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50918; WWE; 1.
PE 4: Predicted;
FT DOMAIN 1227..1267
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 1469..1550
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT REGION 683..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1693 AA; 188995 MW; 6704CDD8C1A129BB CRC64;
MKIDPKTLRP CSAEIFPRCM QLIEHIKSAS DRRTFVERLT EVHEWQPQFG KSEMARWSDV
LNMCDDVLKD AVTCSSSPGA AMAIDEDQTL LTDVTSVLSF TAMLFENTFT RSVYSSTDRL
LNLLDSGNVE IVVETLRLLL VISKRSRFLS QHLSDVQQKK LTVRLSAIAQ CWNGKLRSMK
MDECCTTNVR PSALLPIGFQ TDTNNLVRSV HLDKSFAAEL EHLLSGKNIE EDERASFIAR
LRLVRSFNTS RGRRLSIIAR LLSLSILVYT RSLIEEWAMT TMLYDGLIEE ITRLLLINNT
SESIIDAVKT EALRTLTSIV SLGRPAKLNI VIESLGVNSY HGFLARMTRQ CVDDLRCGRI
GSGYTTVPFC TALFSLLYHL AGFENGGEAL VSCALTETLL GVVSCETLPL ELITFVTRAV
RVIDIMTSLD ANGFISCNGM STIVHRLIFD VNICMKHLAE LSITGPTTEQ CHQQRAALIK
SLLNFIKRAV QDTQFADSTR HIMDSGLPIA LVHILSNCGF FGASLFHNAV CLITNFIYQE
PSLLTSLQDK GVTNAILKTI FREELPTSRD VIAALPNTFT ALCLNDRGLK AFMSENPFDH
FCDIFVSTKY IYAMKCRRNE MNEVALNLGT SFDAFLRHHP TLRESFLNSF AKMLSKLLDV
ASTDSPRCVM SFASCRSTQA TVAVSSTSPS QEEENIMGGN VSSDDDDEDP TSAVANMDEL
HTTENECNQL DLGLSLSIVC DGIPLIPLGE YLLNIGKFLE TLLTHNASPE QADVFVQSGT
ADKLLSLLFV RQIPLELSQS LFPQLVTNII RFLFQHTRSS DVMDMVANRL NKFCLDMLSS
CNTSEDSSKL SLLAMSSSEA SLANICAISV FCSVLSSLSK AALGSNTATK TAVLRFWTNE
GCRLLASCNH AQRIVVWESA VLQIFNATNK CIASTQTDDV QTSEPTEEAN ITLQEDSVGA
DSVPQRIGRP KYLLDDYWLR SKSGTSALNR CNRHCTELLS MLVKISIGGM TRTRRIQENE
GGTPCENAVQ LALQIMKGFQ QALEWKPHDE TDPAIMLPYL AIWINNLSNI LFDERKIPYH
LMLSAFYRTG THDTFFNIIS NYFAPDRDQN YCEVGQLLQA WLSLTERLVS AHLFRHSRYK
MSERLAEAKR FPTEKYLAKC QQDAFRQSNV VFGVLSALPL SEAVSFNICD MIISIYREIV
KGIVPLTEKQ KQAVVTTSED RKKMEAELDG ASIGLLVDMG FDRDAAVDAL LEYSTVPEAA
EYLIATDSLG RLRQSSTDER IDTDETDAED GSGQNGDLNV EFEDVLLKEP ISLNEVPSLD
TRLILSSLCK DVIPILLNLM EHGAELVFST SEVMLVILNE VDDDWRKNML IGEYLVQDIL
LMVDELRCDE TDEKAVISLS TRLHFVCLLW PGIATTYMDV CTEYRLHSVL ISVLDMVVIH
CSKRPAFIRL IAPICLWLDL YDKMLKLLDS KDKVEKAVES YAWKYWDTDE RGGVYTWINY
PPAASHTLTN AFLAGRRNCN ISVGGRQYTV DFPSMSHRNA ESHIERPITI SGRLKDGAIL
SEILTEGNEH KEWDEVVHDR LVPAIIGLLG LANIDAASIH AIFILAARIT RDFKIAREFL
QQGGVQTMIN VSGAAVPSSA VLGALIIRHC LDDEISVRQI FEKTVRTIAA GGYTISPPLT
RWNHIRRDTT NNS
//
