ID A0A1P6CA64_BRUMA Unreviewed; 355 AA.
AC A0A1P6CA64;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=COP9 signalosome complex subunit 4 {ECO:0000256|ARBA:ARBA00014881};
GN Name=Bma-csn-4 {ECO:0000313|EMBL:CDQ00440.1,
GN ECO:0000313|WBParaSite:Bm6859c.1};
GN ORFNames=BM_Bm6859 {ECO:0000313|EMBL:CDQ00440.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm6859c.1};
RN [1] {ECO:0000313|EMBL:CDQ00440.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ00440.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ00440.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ00440.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm6859c.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CSN4 family.
CC {ECO:0000256|ARBA:ARBA00010417}.
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DR EMBL; LN857014; CDQ00440.1; -; Genomic_DNA.
DR EnsemblMetazoa; Bm6859c.1; Bm6859c.1; WBGene00227120.
DR WBParaSite; Bm6859c.1; Bm6859c.1; WBGene00227120.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040134; PSMD12/CSN4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10855; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR10855:SF2; COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 143..309
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 355 AA; 40456 MW; 4211CE94DC2DBC3A CRC64;
MVVSRQFVTD IVAALDDLKP CLVKEVAKAL LNIVQSRLIS YEEQVTQLRF RLADLYEGDG
DSGEAAKILM AIPLETGQRT YPPELKMRTY LRIAQLALDY KNSEEAESFV NRASMLFNDV
SKDDELIVIF KSLYAKVLDH RNKFIEAAQR YYDLSLFQNM LTTSEKLQAL TNAISCTVLA
SPGAQRSRML TTLHKDERCS SLAAYGILQK MYFERLIRND EVMEFEKSLS LHQRVTHDGW
SLLQRAVIEH NFTAVSKIFA NITFEQLAKL LDIDRRQAEK MAWQIIADGR VGGIIDQVDG
IVHFTHAVDE DAIATKDALA EWDQHIAELC QNVNIVTDMI IQKHTLWVDS RKPEA
//
