ID A0A1P6CBF8_BRUMA Unreviewed; 1165 AA.
AC A0A1P6CBF8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=BMA-CYK-3, isoform f {ECO:0000313|EMBL:CDQ03973.1};
DE SubName: Full=Ubiquitinyl hydrolase 1 {ECO:0000313|WBParaSite:Bm7448.1};
GN Name=Bma-cyk-3 {ECO:0000313|EMBL:CDQ03973.1,
GN ECO:0000313|WBParaSite:Bm7448.1};
GN ORFNames=BM_Bm7448 {ECO:0000313|EMBL:CDQ03973.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ03973.1};
RN [1] {ECO:0000313|EMBL:CDQ03973.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ03973.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ03973.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ03973.1};
RG WormBase Consortium;
RA Ghedin E., Paulini M.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm7448.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
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DR EMBL; LN857004; CDQ03973.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1P6CBF8; -.
DR STRING; 6279.A0A1P6CBF8; -.
DR EnsemblMetazoa; Bm7448.1; Bm7448.1; WBGene00227709.
DR WBParaSite; Bm7448.1; Bm7448.1; WBGene00227709.
DR InParanoid; A0A1P6CBF8; -.
DR OMA; HICLGLR; -.
DR OrthoDB; 5474185at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF00443; UCH; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00695; DUSP; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 175..210
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 211..246
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 295..411
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 569..1164
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 1165 AA; 131834 MW; C547B6066A8FD9BE CRC64;
MGNRESSTSL TSLTSLISFE EARNLLSADE LKRLETAWDG RDQIAEDEFF NDVLCHPGIP
RATRTRIFAK FCQGSSKLSF QYFVIGIVIL TKVDKNIRLE FLNNERDLES WIEQPPQLTS
RHSEIHYNFY QVLAGVTHLD EQEVEELEKV FGSINDTKLC KLTRNGFGAL VGGAIADHFI
NGLFRAFDEN DDGLVDFKEL VCGLSASCRG PHTARLNFIA QLFDSDGDGY LSKEDILSLY
AHLNLDKTLQ TIHADELGHA SLTDFVCWAN ETKCVDNLLE IIVQLGHICL GLHPSSAEVE
LTVVCGFKQR VQLDAFTEWN IVSSEWWRQW VHALMSNSKV PPINNASIIT VKQKNDWSYK
VPSLSNEGAP LAQNLVINKD FEAVAPCLWK ALLRWHGSAA REGISLQRRI LPARIVDPTA
VNSTKPIIEL YPLTLLILRH GTATGGWLHS AFEWNKESSL RRLPWCVVSE SRICTIEELL
ELLAHQLHIS DVESARLWTV EIDGSPCKRL LDNDSVTLND LKIQQSAQLL LELRNADMSW
PEEVSCLESS NAEGYTTDNS DSSYILGITG LYNMGNTCYM NSALQCLSNT RPLTNYFIEG
RHKDDMKRLK SKGMVAMEYA NVVKELWSGK KRNIAPIKLR DAIRCAGPVF AERSQHDCQE
FLSILLDLLH EDLNQIENKP FIELNDSDGR PDSIVAKEAW DAHLKRDKSI IVDLFTGQLR
STLTCLNCNA ISCRFDAFTC LQLPIPIDHL LLISVVVVKR DGQIPIRYAF RLSCDTTIGM
FKMKLANASG LLSNSFQILC LNRAGQMMQG VSESVDDDNS SINVYPNDAL LYAFELPAEE
DQSNSECFVA APTVIAAHRK MQYNDSYLLG ATRGCTARVF GVPLILRFTP GKTTGNKLYE
EVWLHVSRFL KNGSAGKQQR TREANRAIDA AEDIRNGYPF DLCCVKLSFE WCSKCAWPAF
CRGCVILSND EIIEDNLMAV AIDWKPTALY LRYQHSVELL CRDDGSVLQA WEVHYRPCSL
VSCLNDFMQA ERLDDVIMCK PCGKKCPTTK ALAIWRLPKI LIIHFKRFVC VKSERRWMKS
CKVVDFPLEN LDLREWLRDP DVKTSTKYSC FAIANHYGAM ASGHYVAYAK NNNQWFSFND
SRCQAVKESH VDKKSAYLLF YERMD
//
